Get started
Author

Koji Morita

Observed names: K. Morita, Morita, Koji
ORCID: 0000-0001-9353-4922
Observed ORCID: 0000-0001-9353-4922
OpenAlex ID: A5083108371
2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug
2002 · Koji Morita, Chikako Hasegawa, et al. · Bioorganic & Medicinal Chemistry Letters · 191
A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization
2019 · Yuuri Hashimoto, Kumiko Koyama, et al. · Clinical Cancer Research · 181
Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads
2016 · Takashi Nakada, Takeshi Masuda, et al. · Bioorganic & Medicinal Chemistry Letters · 176
Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides
2003 · Koji Morita, Miho Takagi, et al. · Bioorganic & Medicinal Chemistry · 132
Effects on RNA Interference in Gene Expression (RNAi) in Cultured Mammalian Cells of Mismatches and the Introduction of Chemical Modifications at the 3′-Ends of siRNAs
2002 · Makiko Hamada, Toshiaki Ohtsuka, et al. · Antisense and Nucleic Acid Drug Development · 110
Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology
2016 · Yusuke Ogitani, Yuki Abe, et al. · Bioorganic & Medicinal Chemistry Letters · 53
3′-Amino-2′,4′-BNA: novel bridged nucleic acids having an N3′→P5′ phosphoramidate linkage
2001 · Satoshi Obika, Mayumi Onoda, et al. · Chemical Communications · 43
2'-O, 4'-C-Ethylene-bridged nucleic acids (ENA) with nuclease-resistance and high affnity for RNA
2001 · K. Morita, C. Hasegawa, et al. · Nucleic Acids Symposium Series · 25
PDF
Novel Immunoliposome Technology for Enhancing the Activity of the Agonistic Antibody against the Tumor Necrosis Factor Receptor Superfamily
2018 · Takako Niwa, Yuji Kasuya, et al. · Molecular Pharmaceutics · 19
Enhancement of the Inhibitory Activity of oatp Antisense Oligonucleotides by Incorporation of 2‘-O,4‘-C-Ethylene-Bridged Nucleic Acids (ENA) without a Loss of Subtype Selectivity
2004 · Miho Takagi, Koji Morita, et al. · Biochemistry · 19
Synthesis and properties of 3′-amino-2′,4′-BNA, a bridged nucleic acid with a N3′→P5′ phosphoramidate linkage
2008 · Satoshi Obika, S.M. Abdur Rahman, et al. · Bioorganic & Medicinal Chemistry · 18
Biologically Stable 2‐5A Analogues containing 3′‐O,4′‐C‐bridged Adenosine as Potent RNase L Agonists
2007 · Koji Morita, Masakatsu Kaneko, et al. · ChemMedChem · 13
Inhibition of VEGF mRNA by 2′-O,4′−C−Ethylene-Bridgednucleicacids (ENA®) Antisense Oligonucleotides and Their Influence on Off-Target Gene Expressions
2006 · Koji Morita, Koji Yamate, et al. · Nucleosides Nucleotides & Nucleic Acids · 10
Improvement of single nucleotide polymorphism genotyping by allele-specific PCR using primers modified with an ENA residue
2005 · Makoto Koizumi, Koji Morita, et al. · Analytical Biochemistry · 10
2′-O,4′-C-Ethylene-Bridged Nucleic Acid (ENATM) for Effective Antisense Formation
2003 · Koji Morita, Koji Yamate, et al. · Nucleosides Nucleotides & Nucleic Acids · 9
Immune Responses and Antitumor Effect through Delivering to Antigen Presenting Cells by Optimized Conjugates Consisting of CpG-DNA and Antigenic Peptide
2020 · Hitomi Irie, Koji Morita, et al. · Bioconjugate Chemistry · 8
Synthesis of ENA Nucleotides and ENA Oligonucleotides
2018 · Koji Morita, Makoto Koizumi · Current Protocols in Nucleic Acid Chemistry · 7
Abstract 3092: U3-1402a, a novel HER3-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent antitumor efficacy
2017 · Suguru Ueno, Kenji Hirotani, et al. · Cancer Research · 7
Down-regulation of VEGF mRNA expression by 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) antisense oligonucleotides and investigation of non-target gene expression
2002 · K. Morita, K. Yamate, et al. · Nucleic Acids Symposium Series · 7
PDF
Effect of Spacers on the Affinity of Tyrosine-Modified Polymers to L-Type Amino Acid Transporter 1
2025 · Yan Ming Voon, Haochen Guo, et al. · Biomacromolecules · 6
Comparison Between Properties Of 2′-O,4′-C-Ethylene-Bridged Nucleic Acid (Ena®) Phosphorothioate Oligonucleotides And N3′-P5′ Thiophosphoramidate Oligonucleotides
2006 · Makiko Horie, Koji Morita, et al. · Nucleosides Nucleotides & Nucleic Acids · 6
SNP genotyping by allele-specific PCR using ENA® primers
2005 · Makoto Koizumi, Koji Morita, et al. · Nucleic Acids Symposium Series · 5
PDF
Tyrosinase-Related Protein2 Peptide with Replacement of N-Terminus Residue by Cysteine Binds to H-2Kb and Induces Antigen-Specific Cytotoxic T Lymphocytes after Conjugation with CpG-DNA
2023 · Hitomi Irie, Koji Morita, et al. · Bioconjugate Chemistry · 3
An improved synthesis of 2′-O,4′-C-ethylene nucleic acid (ENA) and thermodynamic studies of duplex formation containing the guanosine ENA unit
2020 · Miho Takagi-Sato, Koji Morita, et al. · Nucleosides Nucleotides & Nucleic Acids · 3
Abstract A145: DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent anti-tumor efficacy with differentiation from T-DM1 in preclinical studies
2015 · Yusuke Ogitani, Junko Yamaguchi, et al. · Molecular Cancer Therapeutics · 3
Works count: 36
Citation count: 1,072
H-index: 12
I10-index: 14
Year
Topic
Type