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Patrick F. Cullen
Observed names:
P. Cullen,
P.F. Cullen,
Patrick Cullen
Institution:
Biogen (United States)
Observed institutions:
Biogen (United States),
Ionis Pharmaceuticals (United States)
OpenAlex ID:
A5083130166
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
2010
·
Douglas J. Marcotte
, Yu‐Ting Liu
, et al.
·
Protein Science
·
159
PDF
SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage
2017
·
Mohini Jangi
, Christina Fleet
, et al.
·
Proceedings of the National Academy of Sciences
·
134
Cx3cr1- deficient microglia exhibit a premature aging transcriptome
2019
·
Stefka Gyoneva
, Raghavendra Hosur
, et al.
·
Life Science Alliance
·
110
PDF
Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus
2019
·
Michelle Petri
, Wei Fu
, et al.
·
BMC Medical Genomics
·
88
PDF
Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation
2020
·
Alex R. D. Delbridge
, Dann Huh
, et al.
·
Frontiers in Cellular Neuroscience
·
73
PDF
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response
2021
·
Kathryn Pellerin
, Stephen J Rubino
, et al.
·
Brain
·
66
Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms
2016
·
Melanie S. Brennan
, Hiral Patel
, et al.
·
Antioxidants and Redox Signaling
·
59
Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments
2016
·
Haiyan Peng
, Huo Li
, et al.
·
Journal of Neuroimmunology
·
57
Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients
2019
·
Loubna Chadli
, Britt Sotthewes
, et al.
·
Scientific Reports
·
50
PDF
Small molecule mediated inhibition of ROR γ ‐dependent gene expression and autoimmune disease pathology in vivo
2015
·
Daliya Banerjee
, Linlin Zhao
, et al.
·
Immunology
·
50
Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE
2025
·
Amelia Schroeder
, Melanie L. Loth
, et al.
·
Nature Methods
·
37
Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7
2015
·
John F. Staropoli
, Huo Li
, et al.
·
Genomics
·
37
In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model
2022
·
Yi A. Chen
, Mark W. Kankel
, et al.
·
Gene Therapy
·
34
PDF
Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells
2021
·
Eris Bame
, Hao Tang
, et al.
·
Clinical & Translational Immunology
·
31
Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren’s Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis
2016
·
Scott Haskett
, Jian Ding
, et al.
·
The Journal of Immunology
·
29
Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection
2023
·
Shukkwan K. Chen
, Zachary C.E. Hawley
, et al.
·
Molecular Therapy — Nucleic Acids
·
27
Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice
2024
·
Zachary C.E. Hawley
, Ingrid D. Pardo
, et al.
·
Molecular Therapy
·
26
A Kinase‐focused Compound Collection: Compilation and Screening Strategy
2006
·
Dongyu Sun
, Claudio Chuaqui
, et al.
·
Chemical Biology & Drug Design
·
20
Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
2019
·
Brian T. Hopkins
, Eris Bame
, et al.
·
Bioorganic & Medicinal Chemistry
·
17
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
2021
·
Brian T. Hopkins
, Eris Bame
, et al.
·
Bioorganic & Medicinal Chemistry
·
13
Increased systemic HSP70B levels in spinal muscular atrophy infants
2021
·
Eric J. Eichelberger
, Christiano R. R. Alves
, et al.
·
Annals of Clinical and Translational Neurology
·
9
Characterizing the composition of iPSC derived cells from bulk transcriptomics data with CellMap
2022
·
Zhengyu Ouyang
, Nathanael Bourgeois-Tchir
, et al.
·
Scientific Reports
·
6
PDF
PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson’s disease risk, RNA expression, and DNA methylation
2021
·
Orly Goldstein
, Mali Gana-Weisz
, et al.
·
Journal of genetics and genomics/Journal of Genetics and Genomics
·
6
Dimethyl Fumarate and Monomethyl Fumarate are Distinguished by Non-Overlapping Pharmacodynamic Effects In Vivo (P1.206)
2014
·
Melanie Brennan
, Normand Allaire
, et al.
·
Neurology
·
6
Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy
2025
·
Branka Grubor
, Kate L. Henry
, et al.
·
Molecular Therapy — Methods & Clinical Development
·
5
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Works count:
33
Citation count:
1,162
H-index:
18
I10-index:
20
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