Author

Kazunari Sakagami

Observed names: K Sakagami, Sakagami, K.

Institution: Taisho Pharmaceutical (Japan)

Observed institutions: Aoyama Gakuin University, Taisho Pharmaceutical (Japan), Tokyo University of Pharmacy and Life Sciences, Kyoto University

OpenAlex ID: A5083223952

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 · Shigeyuki Chaki, Ryoko Yoshikawa, et al. · Neuropharmacology · 262

Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

2000 · Atsuro Nakazato, Toshihito Kumagai, et al. · Journal of Medicinal Chemistry · 116

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

2004 · Atsuro Nakazato, Kazunari Sakagami, et al. · Journal of Medicinal Chemistry · 60

Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential

2006 · Akito Yasuhara, Masato Nakamura, et al. · Bioorganic & Medicinal Chemistry · 43

Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist

2008 · Kazunari Sakagami, Akito Yasuhara, et al. · Bioorganic & Medicinal Chemistry · 21

Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists

2006 · Akito Yasuhara, Kazunari Sakagami, et al. · Bioorganic & Medicinal Chemistry · 16

In Vitro and in Vivo Evaluation of the Metabolism and Bioavailability of Ester Prodrugs of Mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a Potent Metabotropic Glutamate Receptor Antagonist

2005 · Masato Nakamura, Yasunori Kawakita, et al. · Drug Metabolism and Disposition · 14

Convenient method for the preparation of 1-phenylthio-3-alken-1-ynes and 4-hydroxy-1-phenylthio-1,2-alkadienes from a common precursor

2002 · Atsushi Ogawa, Kazunari Sakagami, et al. · Tetrahedron Letters · 10

Scalable Synthesis of (+)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid as a Potent and Selective Group II Metabotropic Glutamate Receptor Agonist

2007 · Kazunari Sakagami, Toshihito Kumagai, et al. · Chemical and Pharmaceutical Bulletin · 6

CCDC 673815: Experimental Crystal Structure Determination

2008 · Sakagami, K., Yasuhara, A., et al. · The Cambridge Structural Database

Convenient Method for the Preparation of 1‐Phenylthio‐3‐alken‐1‐ynes and 4‐Hydroxy‐1‐phenylthio‐1,2‐alkadienes from a Common Precursor.

2002 · Atsushi Ogawa, Kazunari Sakagami, et al. · ChemInform

In vitro pharmacological properties of MGS compounds, selective and potent group II metabotropic glutamate receptors agonists

2000 · Sulalita Chaki, S. Okuyama, et al. · The Society for Neuroscience Abstracts

Synthesis of cyclodeca-1,5-diyne derivatives having o-nitrophenylseleno group.

1997 · M Michida, K Sakagami, et al. · PubMed

Furanoside derivatives having aziridinyl group or ethynyl group and related compounds. Preparation and their reaction with oligodeoxyribonucleotide

1995 · Hironori Tanaka, Kimiko Mizutani, et al. · Institutional Repositories DataBase (IRDB)

Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides.

1995 · K Sakagami, H Yamaga, et al. · PubMed

Works count: 15

Citation count: 548

H-index: 8

I10-index: 8