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Duncan S. Holmes

Observed names: D. HOLMES, D. Holmes, D. S. HOLMES, D.S. Holmes, DUNCAN S. HOLMES, Duncan Holmes, Duncan S Holmes
ORCID: 0000-0002-7958-8606
Observed ORCID: 0000-0002-7958-8606
OpenAlex ID: A5083365899
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
2016 · Damian J Mole, Scott P Webster, et al. · Nature Medicine · 162
Synthesis and Structure−Activity Relationships of Long-acting β2Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach
2010 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Journal of Medicinal Chemistry · 101
Chemoselective Glycosylations. 2. Differences in Size of Anomeric Leaving Groups Can Be Exploited in Chemoselective Glycosylations
1997 · Richard Geurtsen, Duncan S. Holmes, et al. · The Journal of Organic Chemistry · 80
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
2008 · Richard Angell, Nicola M. Aston, et al. · Bioorganic & Medicinal Chemistry Letters · 78
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
2021 · David A. Lomas, James A. Irving, et al. · EMBO Molecular Medicine · 64
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration
2009 · Michael D. Woodrow, Stuart P. Ballantine, et al. · Bioorganic & Medicinal Chemistry Letters · 56
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
2017 · Jonathan P. Hutchinson, Paul Rowland, et al. · Nature Communications · 51
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p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression
2009 · Nicola M. Aston, Paul Bamborough, et al. · Journal of Medicinal Chemistry · 46
Chemoselective glycosylations (part 1): Differences in size of anomeric leaving groups can be exploited in chemoselective glycosylations
1995 · Geert-Jan Boons, Richard Geurtsen, et al. · Tetrahedron Letters · 44
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation
2020 · John Liddle, Jonathan P. Hutchinson, et al. · Journal of Medicinal Chemistry · 43
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome
2021 · John Liddle, Veronique Beneton, et al. · Journal of Investigative Dermatology · 39
Synthesis of Putative Intermediates on the Monensin Biosynthetic Pathway and Incorporation Experiments with the Monensin‐Producing Organism
1990 · Duncan S. Holmes, John A. Sherringham, et al. · Helvetica Chimica Acta · 38
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
2017 · Ann L. Walker, Nicolas Ancellin, et al. · Journal of Medicinal Chemistry · 37
Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate character
1996 · Mark J. Bamford, Michael Bird, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Homeomorphic Isomerism in a Peptidic Macrobicycle
1996 · Richard S. Wareham, Jeremy D. Kilburn, et al. · Angewandte Chemie International Edition in English · 35
Discovery of a Brain-Penetrant S1P3-Sparing Direct Agonist of the S1P1 and S1P5 Receptors Efficacious at Low Oral Dose
2011 · Emmanuel H. Demont, Sandra Arpino, et al. · Journal of Medicinal Chemistry · 34
Synthesis of a novel analogue of sialyl Lewis X
1995 · Jeremy C. Prodger, Mark J. Bamford, et al. · Tetrahedron Letters · 34
The Discovery of Phthalazinone-Based Human H1and H3Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis
2011 · Panayiotis A. Procopiou, Christopher Browning, et al. · Journal of Medicinal Chemistry · 33
In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
2017 · Andrew McBride, Anna M. Hoy, et al. · Scientific Reports · 30
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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors
2009 · John Liddle, Paul Bamborough, et al. · Bioorganic & Medicinal Chemistry Letters · 29
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy
2012 · John Liddle, Paul Bamborough, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate
2011 · Emmanuel H. Demont, Benjamin I. Andrews, et al. · ACS Medicinal Chemistry Letters · 27
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice
2021 · Andrew C. Pearce, Mark J. Bamford, et al. · Journal of Biological Chemistry · 26
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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists
2007 · Panayiotis A. Procopiou, Rachael A. Ancliff, et al. · Journal of Medicinal Chemistry · 26
Discovery of a Rapidly Metabolized, Long-Acting β2Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing
2013 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Journal of Medicinal Chemistry · 23
Works count: 56
Citation count: 1,454
H-index: 24
I10-index: 40
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