Get started
Author

Jayshree L. Hirpara

Observed names: Hirpara, Jayshree L., J L Hirpara, J. Hirpara, J.L. Hirpara, JL Hirpara, Jayshree Hirpara, Jayshree L Hirpara
Observed institutions: Griffith University, National University of Singapore, University of Southern Denmark, National University Cancer Institute, Singapore, National University Hospital, National University Health System, Cancer Science Institute of Singapore
ORCID: 0000-0002-1454-9163
Observed ORCID: 0000-0002-1454-9163
OpenAlex ID: A5083386422
Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
2010 · Chew Hooi Wong, Kartini Bte Iskandar, et al. · PLoS ONE · 264
PDF
Do STAT3 inhibitors have potential in the future for cancer therapy?
2017 · Andrea L.A. Wong, Jayshree L. Hirpara, et al. · Expert Opinion on Investigational Drugs · 227
PDF
Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies
2015 · A.L. Wong, R.A. Soo, et al. · Annals of Oncology · 175
Intracellular Acidification Triggered by Mitochondrial-derived Hydrogen Peroxide Is an Effector Mechanism for Drug-induced Apoptosis in Tumor Cells
2001 · Jayshree L. Hirpara, Marie-Véronique Clément, et al. · Journal of Biological Chemistry · 145
Hydrogen Peroxide-Mediated Cytosolic Acidification Is a Signal for Mitochondrial Translocation of Bax during Drug-Induced Apoptosis of Tumor Cells
2004 · Kashif A. Ahmad, Kartini B. Iskandar, et al. · Cancer Research · 130
Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
2018 · Matilda Lee, Jayshree L. Hirpara, et al. · Redox Biology · 127
PDF
Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance
2018 · Jayshree Hirpara, Jie Qing Eu, et al. · Redox Biology · 123
PDF
Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria
2003 · M-V Clément, J L Hirpara, et al. · Cell Death and Differentiation · 107
The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
2011 · Rathiga Velaithan, Jia Kang, et al. · Blood · 85
Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
2021 · Brittney Joy-Anne Foo, Jie Qing Eu, et al. · Oxidative Medicine and Cellular Longevity · 56
PDF
Targeting Cell Metabolism as Cancer Therapy
2019 · Natalie Y.L. Ngoi, Jie Qing Eu, et al. · Antioxidants and Redox Signaling · 51
Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells
2000 · Jayshree L. Hirpara, Mohamed A. Seyed, et al. · Blood · 51
Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma
2016 · Ser Yue Loo, Jayshree L. Hirpara, et al. · Antioxidants and Redox Signaling · 49
LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization
2007 · T W Poh, S Huang, et al. · Cell Death and Differentiation · 42
Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide
2015 · Jia Kang, Stephen Jun Fei Chong, et al. · Oncotarget · 39
PDF
A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS
2024 · Kartini Iskandar, Jonathan Foo, et al. · Autophagy · 35
PDF
Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc
2020 · Deepika Raman, Stephen J.F. Chong, et al. · Redox Biology · 26
PDF
A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression
2019 · Stephen Jun Fei Chong, Jolin Xiao Hui Lai, et al. · Cancer Letters · 26
Cleavage of Misfolded Nuclear Receptor Corepressor Confers Resistance to Unfolded Protein Response–Induced Apoptosis
2006 · Angela Ping Ping Ng, Jek Howe Fong, et al. · Cancer Research · 22
FLIP: A flop for execution signals
2012 · Kothandharaman Subramaniam, Jayshree L. Hirpara, et al. · Cancer Letters · 21
Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
2019 · Jayshree L. Hirpara, Kothandharaman Subramaniam, et al. · Redox Biology · 19
PDF
Understanding the cancer stem cell phenotype: A step forward in the therapeutic management of cancer
2019 · Andrea Li Ann Wong, Gregory Lucien Bellot, et al. · Biochemical Pharmacology · 18
METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity
2024 · Bernice Woon Li Lee, You Heng Chuah, et al. · Cell Death and Disease · 15
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance
2024 · Jayshree Hirpara, Win Lwin Thuya, et al. · Theranostics · 13
PDF
Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
2016 · Chew Hooi Wong, Kartini Bte Iskandar, et al. · PLoS ONE · 13
PDF
Works count: 53
Citation count: 1,932
H-index: 20
I10-index: 27
Year
Topic
Type