Author

Ronald Palin

Observed names: Palin, R., Palin, Ronald, R. Palin

Observed institutions: Heriot-Watt University, University of Glasgow

OpenAlex ID: A5083430442

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

2002 · Anton Bom, Mark Bradley, et al. · Angewandte Chemie International Edition · 456

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure−Activity Relationships

2002 · Julia M. Adam, D. Jonathan Bennett, et al. · Journal of Medicinal Chemistry · 234

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

2002 · Anton Bom, Mark Bradley, et al. · Angewandte Chemie · 225

Modified γ-Cyclodextrins and Their Rocuronium Complexes

2002 · K. S. Cameron, J. K. Clark, et al. · Organic Letters · 36

Novel Piperidinium and Pyridinium Agents as Water-Soluble Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Blockade

2002 · Ronald Palin, John K. Clark, et al. · Bioorganic & Medicinal Chemistry Letters · 33

Mutual induced fit in cyclodextrin–rocuronium complexes

2005 · Alan Cooper, Margaret Nutley, et al. · Organic & Biomolecular Chemistry · 31

The Hypnotic, Electroencephalographic, and Antinociceptive Properties of Nonpeptide ORL1 Receptor Agonists After Intravenous Injection in Rodents

2006 · Alan J. Byford, Alison Anderson, et al. · Anesthesia & Analgesia · 26

Structure–activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

2010 · Ronald Palin, Lynn Abernethy, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Quaternary Salts of E2020 Analogues as Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Block

2002 · John K Clark, Phill Cowley, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties

2008 · Ronald Palin, John K. Clark, et al. · Bioorganic & Medicinal Chemistry · 22

Mono-6-( O -2,4,6-triisopropylbenzenesulfonyl)-γ-cyclodextrin, a novel intermediate for the synthesis of mono-functionalised γ-cyclodextrins

2001 · Ronald Palin, Simon J.A Grove, et al. · Tetrahedron Letters · 20

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties

2006 · Ronald Palin, Anton Bom, et al. · Bioorganic & Medicinal Chemistry · 18

Chemical chelation as a novel method of NMB reversal - discovery of Org 25969

2001 · A. Bom, K. Cameron, et al. · European Journal of Anaesthesiology · 14

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

2004 · Ronald Palin, David R. Barn, et al. · Bioorganic & Medicinal Chemistry Letters · 13

New approaches to reversal of neuromuscular block.

2002 · Anton Bom, John K Clark, et al. · PubMed · 13

The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists

2010 · Phillip M. Cowley, James Baker, et al. · Bioorganic & Medicinal Chemistry Letters · 6

Asymmetric synthesis of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one derivatives, potent and selective NOP agonists

2008 · John K. Clark, Philip S. Jones, et al. · Tetrahedron · 6

Quaternary Salts of E2020 Analogues as Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Block.

2003 · John K. Clark, Phill Cowley, et al. · ChemInform · 4

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach

2009 · Ronald Palin, John K. Clark, et al. · Bioorganic & Medicinal Chemistry Letters · 3

Novel Piperidinium and Pyridinium Agents as Water‐Soluble Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Blockade.

2003 · Ronald Palin, John K. Clark, et al. · ChemInform · 1

CCDC 658439: Experimental Crystal Structure Determination

2008 · Clark, J.K., Jones, P.S., et al. · The Cambridge Structural Database

CCDC 658438: Experimental Crystal Structure Determination

2008 · Clark, J.K., Jones, P.S., et al. · The Cambridge Structural Database

NMR spectra and dynamics of the sodium salt of per(6‐thiobenzoic acid)‐γ‐cyclodextrin

2005 · K. S. Cameron, L. Fielding, et al. · Magnetic Resonance in Chemistry

Synthesis and SAR Studies of 3‐Phenoxypropyl Piperidine Analogues as ORL1 (NOP) Receptor Agonists.

2005 · Ronald Palin, et al. et al. · ChemInform

CCDC 253403: Experimental Crystal Structure Determination

2005 · Cooper, A., Nutley, M., et al. · The Cambridge Structural Database

Works count: 31

Citation count: 1,210

H-index: 13

I10-index: 15