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Alexander Flohr

Observed names: A. FLOHR, A. Flohr
ORCID: 0000-0001-6847-5780
Observed ORCID: 0000-0001-6847-5780
OpenAlex ID: A5083542163
Scaffold hopping
2004 · Hans-Joachim Böhm, Alexander Flohr, et al. · Drug Discovery Today Technologies · 335
Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
2009 · Leopoldo Luistro, Wei He, et al. · Cancer Research · 191
Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation
2007 · Richard M. Page, Karlheinz Baumann, et al. · Journal of Biological Chemistry · 165
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An Antibody-Catalyzed Allylic Sulfoxide−Sulfenate Rearrangement
1999 · Zhaohui S. Zhou, Alexander Flohr, et al. · The Journal of Organic Chemistry · 38
A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios
2022 · Andreas Tosstorff, Markus G. Rudolph, et al. · Journal of Computer-Aided Molecular Design · 33
α-Functionalized Phosphonylphosphinates: Synthesis and Evaluation as Transcarbamoylase Inhibitors
1999 · Alexander Flohr, Andreas Aemissegger, et al. · Journal of Medicinal Chemistry · 30
Stille coupling versus cine substitution. Electronic effects also influence coupling sterically hindered stannanes
1998 · Alexander Flohr · Tetrahedron Letters · 30
Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction
2022 · Gerald Gavory, Mahmoud Ghandi, et al. · Cancer Research · 26
Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors
2007 · Eric A. Kitas, Guido Galley, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Aminothiazoles as γ-secretase modulators
2011 · Thomas Lübbers, Alexander Flohr, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors
2009 · Fabienne Hoffmann-Emery, Roland Jakob-Roetne, et al. · Tetrahedron Letters · 15
LiClO4 and Organic Solvents - a powerful combination. 15
1995 · Alexander Flohr, Herbert Waldmann · Journal für praktische Chemie · 15
Targeted γ-Secretase Inhibition To Control the Notch Pathway in Renal Diseases
2015 · Lucienne Juillerat-Jeanneret, Alexander Flohr, et al. · Journal of Medicinal Chemistry · 14
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists
2010 · Adrian Wai-Hing Cheung, John Brinkman, et al. · Bioorganic & Medicinal Chemistry Letters · 12
The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat
2012 · Leon M. Tai, Helmut Jacobsen, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 9
Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells
2012 · Maria Cristina de Vera Mudry, Franziska Regenass-Lechner, et al. · International Journal of Alzheimer s Disease · 7
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Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer
2021 · Gerald Gavory, Bernhard Fasching, et al. · Molecular Cancer Therapeutics · 5
Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor
2017 · Alexander Flohr, Roman Hutter, et al. · Bioorganic & Medicinal Chemistry Letters · 5
EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib
2019 · Matthew O’Connor, Jie Zhang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Abstract LB-111: Epidermal growth factor receptor oncogenes expressed in glioblastoma are activated as covalent dimers and exhibit unique pharmacology
2019 · Matthew O'Connor, Theodore Nicolaides, et al. · Cancer Research · 2
Abstract LB140: CNS penetrant, irreversible inhibitors potently inhibit the family of allosteric oncogenic EGFR mutants expressed in GBM and demonstrate efficacy in patient-derived xenograft models
2021 · Matthew O'Connor, Matt Lucas, et al. · Cancer Research · 1
Identification of a patient tissue-based phosphorylation site as a biomarker for epidermal growth factor receptor (EGFR) activity in non-small cell lung cancer.
2024 · Nithya Raman, Alexander Flohr, et al. · Journal of Clinical Oncology
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Data from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
2023 · Leopoldo Luistro, Wei He, et al.
Supplementary Methods and Materials from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
2023 · Leopoldo Luistro, Wei He, et al.
Supplementary Figure 2 from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
2023 · Leopoldo Luistro, Wei He, et al.
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Works count: 41
Citation count: 982
H-index: 13
I10-index: 14
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