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Punit P. Seth

Observed names: P. P. SETH, P. P. Seth, P.P. Seth, Punit P Seth, Punit Seth, Punit P Seth, Punit P. Seth, Seth, P. P., Seth, P.P., Seth, Punit, Seth, Punit P.
Observed institutions: University of Bern, University of Iowa, University of British Columbia, Alnylam Pharmaceuticals (United States), Vanderbilt University, Ionis Pharmaceuticals (United States), Child and Family Research Institute, The Ohio State University, Université de Montréal, Syracuse University
ORCID: 0000-0002-1783-7806
Observed ORCID: 0000-0002-1783-7806
OpenAlex ID: A5084516005
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice
2014 · Thazha P. Prakash, Mark J. Graham, et al. · Nucleic Acids Research · 611
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The Medicinal Chemistry of Therapeutic Oligonucleotides
2016 · W. Brad Wan, Punit P. Seth · Journal of Medicinal Chemistry · 429
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
2019 · Wen Shen, Cheryl L. De Hoyos, et al. · Nature Biotechnology · 346
Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
2008 · Punit P. Seth, Andrew Siwkowski, et al. · Journal of Medicinal Chemistry · 266
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Single-Stranded siRNAs Activate RNAi in Animals
2012 · Walt F. Lima, Thazha P. Prakash, et al. · Cell · 256
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Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts
2015 · Sebastien A. Burel, Christopher E. Hart, et al. · Nucleic Acids Research · 216
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Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′ O -Methoxyethyl and 2′,4′-Constrained 2′ O -Ethyl Nucleic Acid Analogues
2010 · Punit P. Seth, Guillermo Vasquez, et al. · The Journal of Organic Chemistry · 211
Targeted delivery of antisense oligonucleotides to pancreatic β-cells
2018 · C. Ämmälä, W. J. Drury, et al. · Science Advances · 188
SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain
2005 · Punit P. Seth, Alycia Miyaji, et al. · Journal of Medicinal Chemistry · 173
Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver
2016 · Colton M. Miller, Aaron J. Donner, et al. · Nucleic Acids Research · 171
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
2013 · Michael E. Østergaard, Amber L. Southwell, et al. · Nucleic Acids Research · 163
Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
2019 · Thazha P Prakash, Adam E Mullick, et al. · Nucleic Acids Research · 162
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Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes
2017 · Michael Tanowitz, Lisa Hettrick, et al. · Nucleic Acids Research · 157
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In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
2014 · Amber L Southwell, Niels H Skotte, et al. · Molecular Therapy · 145
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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
2018 · Hans J Gaus, Ruchi Gupta, et al. · Nucleic Acids Research · 144
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
2021 · Tetsuya Nagata, Chrissa A. Dwyer, et al. · Nature Biotechnology · 140
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
2021 · Brooke A Anderson, Graeme C Freestone, et al. · Nucleic Acids Research · 134
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Comprehensive Structure–Activity Relationship of TriantennaryN-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes
2016 · Thazha P. Prakash, Jinghua Yu, et al. · Journal of Medicinal Chemistry · 131
DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing
2015 · Kazutaka Nishina, Wenying Piao, et al. · Nature Communications · 130
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
2019 · Michael T Migawa, Wen Shen, et al. · Nucleic Acids Research · 129
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Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
2018 · Amber L. Southwell, Holly B. Kordasiewicz, et al. · Science Translational Medicine · 126
Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
2014 · W. Brad Wan, Michael T. Migawa, et al. · Nucleic Acids Research · 126
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The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents
2020 · Stanley T. Crooke, Punit P. Seth, et al. · Journal of the American Chemical Society · 124
Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients
2014 · Niels H. Skotte, Amber L. Southwell, et al. · PLoS ONE · 115
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Selective tissue targeting of synthetic nucleic acid drugs
2019 · Punit P. Seth, Michael Tanowitz, et al. · Journal of Clinical Investigation · 109
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Works count: 176
Citation count: 8,692
H-index: 51
I10-index: 116
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