Get started
Author

Jianghua Tu

Effects of Genetic Polymorphisms of Cyp3a4 , Cyp3a5 and Mdr1 on Cyclosporine Pharmacokinetics After Renal Transplantation
2006 · Yong‐Fang Hu, Wen Qiu, et al. · Clinical and Experimental Pharmacology and Physiology · 98
Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism
2009 · Yi-Jing He, Wei Zhang, et al. · Clinica Chimica Acta · 88
Simultaneous Action of the Flavonoid Quercetin on Cytochrome P450 (cyp) 1a2, Cyp2a6, N‐acetyltransferase and Xanthine Oxidase Activity in Healthy Volunteers
2009 · Yao Chen, Peng Xiao, et al. · Clinical and Experimental Pharmacology and Physiology · 73
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis
2019 · Jianghua Tu, Soohyun Park, et al. · Scientific Reports · 66
PDF
Effect of glycyrrhizin on the activity of CYP3A enzyme in humans
2010 · Jiang-Hua Tu, Yi-Jing He, et al. · European Journal of Clinical Pharmacology · 64
Association of CYP3A4*18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects
2007 · Y.-F. Hu, J.-H. Tu, et al. · Xenobiotica · 61
Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases
2020 · Soohyun Park, Ling Wu, et al. · Science Signaling · 46
Rosiglitazone via PPAR γ‐dependent suppression of oxidative stress attenuates endothelial dysfunction in rats fed homocysteine thiolactone
2015 · Xu‐Hong Yang, Peng Li, et al. · Journal of Cellular and Molecular Medicine · 44
PDF
Clopidogrel Inhibits CYP2C19‐Dependent Hydroxylation of Omeprazole Related to CYP2C19 Genetic Polymorphisms
2009 · B. L. Chen, Y. Chen, et al. · The Journal of Clinical Pharmacology · 44
Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes
2010 · J.-H. Tu, D.-L. Hu, et al. · Xenobiotica · 40
Effects of theCYP2C9*13allele on the pharmacokinetics of losartan in healthy male subjects
2009 · Z. Li, G. Wang, et al. · Xenobiotica · 30
Hepatic Nuclear Factor 1α Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 Substrate Rosuvastatin and Bilirubin
2008 · Yi-Jing He, Wei Zhang, et al. · Drug Metabolism and Disposition · 30
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers
2009 · Y. Chen, J.-H. Tu, et al. · Xenobiotica · 27
LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands
2023 · Yukimatsu Toh, Ling Wu, et al. · Scientific Reports · 16
PDF
Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment
2021 · Jie Cui, Yukimatsu Toh, et al. · Journal of Medicinal Chemistry · 14
Antitumor Activity of a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma
2024 · Jianghua Tu, Yukimatsu Toh, et al. · Pharmaceutics · 9
Anti-tumor activity of camptothecin analog conjugate of an RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
2025 · Yukimatsu Toh, Ling Wu, et al. · British Journal of Cancer · 4
PDF
Loss of ZNRF3/RNF43 unleashes EGFR in cancer
2026 · Fei Yue, Amy T. Ku, et al. · eLife · 3
Loss of ZNRF3/RNF43 unleashes EGFR in cancer
2024 · Fei Yue, Amy T Ku, et al. · eLife · 3
PDF
[Protective effect of Na(+)-H+ exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia].
2002 · Jiang-hua Tu, Li-ying Liu, et al. · PubMed · 3
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
2025 · Fei Yue, Amy T Ku, et al. · eLife · 2
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
2024 · Fei Yue, Amy T. Ku, et al. · eLife · 2
RSPO2-Based Peptibodies Conjugated with Pyrrolobenzodiazepine Dimer or Camptothecin Analogs Demonstrate Potent Antitumor Activity by Targeting the Three Receptors LGR4/5/6 in Colorectal Cancer and Neuroblastoma
2026 · Yukimatsu Toh, Jianghua Tu, et al. · Journal of Medicinal Chemistry · 1
PDF
Abstract 2956: Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
2025 · Yukimatsu Toh, Ling Wu, et al. · Cancer Research
Author response: Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
2025 · Fei Yue, Amy T Ku, et al.
PDF
Works count: 25
Citation count: 768
H-index: 14
I10-index: 15
Year
Topic
Type