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Oleksandra D. Prysyazhna

Observed names: O. D. Prysyazhna, O. Prysyazhna, Oleksandra Prysyazhna, Prysyazhna, Oleksandra
Observed institutions: University of Siena, Uppsala University, University College Hospital, St George's Hospital, St Thomas' Hospital, National Academy of Sciences of Ukraine, Queen Mary University of London, King's College London, Barts Health NHS Trust, University Hospital Regensburg, British Heart Foundation, National Institute for Health and Care Research, University of Oxford, University Medical Center of the Johannes Gutenberg University Mainz, Bogomoletz Institute of Physiology, Universitätsmedizin Göttingen, William Harvey Research Institute
ORCID: 0000-0002-0394-7000
Observed ORCID: 0000-0002-0394-7000
OpenAlex ID: A5089123737
Mapping the human genetic architecture of COVID-19
2021 · COVID-19 Host Genetics Initiative, COVID-19 Host Genetics InitiativeLeadership, et al. · Nature · 983
Whole-genome sequencing reveals host factors underlying critical COVID-19
2022 · Athanasios Kousathanas, Erola Pairo-Castineira, et al. · Nature · 327
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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
2023 · Erola Pairo-Castineira, Konrad Rawlik, et al. · Nature · 224
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Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
2012 · Oleksandra Prysyazhna, Olena Rudyk, et al. · Nature Medicine · 175
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy
2020 · Mariana Fernandez-Caggiano, Alisa Kamynina, et al. · Nature Metabolism · 132
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A second update on mapping the human genetic architecture of COVID-19
2023 · The COVID-19 Host Genetics Initiative, Leadership, et al. · Nature · 120
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Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
2019 · Christopher P. Stanley, Ghassan J. Maghzal, et al. · Nature · 112
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Protein Kinase G Iα Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide
2014 · Daniel Stubbert, Oleksandra Prysyazhna, et al. · Hypertension · 104
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Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
2014 · Rebecca L. Charles, Olena Rudyk, et al. · Proceedings of the National Academy of Sciences · 99
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cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation
2012 · Joseph Robert Burgoyne, Oleksandra Prysyazhna, et al. · Hypertension · 86
Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase
2019 · Oleksandra Prysyazhna, Kathryn Wolhuter, et al. · Circulation · 81
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure
2017 · Can Martin Sag, Moritz Schnelle, et al. · Circulation · 62
Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling
2015 · Rajesh K. Mistry, Thomas V.A. Murray, et al. · Journal of Biological Chemistry · 57
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Protein kinase G oxidation is a major cause of injury during sepsis
2013 · Olena Rudyk, Alkystis Phinikaridou, et al. · Proceedings of the National Academy of Sciences · 54
Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice
2015 · Joseph R. Burgoyne, Olena Rudyk, et al. · Nature Communications · 53
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Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1α Knock-In Mouse
2012 · Olena Rudyk, Oleksandra Prysyazhna, et al. · Circulation · 52
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
2016 · Jenna Scotcher, Oleksandra Prysyazhna, et al. · Nature Communications · 49
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Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling
2019 · Martin Feelisch, Takaaki Akaike, et al. · Cardiovascular Research · 46
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Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation
2016 · Oleksandra Prysyazhna, Joseph Robert Burgoyne, et al. · Journal of Biological Chemistry · 46
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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
2021 · Chiara Fallerini, Nicola Picchiotti, et al. · Human Genetics · 37
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Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)
2017 · Joseph R. Burgoyne, Oleksandra Prysyazhna, et al. · Hypertension · 28
Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability
2015 · Mariana Fernández-Caggiano, Oleksandra Prysyazhna, et al. · Molecular & Cellular Proteomics · 28
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Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation
2016 · Soichiro Akashi, Khandaker Ahtesham Ahmed, et al. · Biochemistry · 27
Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system
2015 · Oleksandra Prysyazhna, Philip Eaton · Frontiers in Pharmacology · 25
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Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity
2017 · Sonia Donzelli, Mara Goetz, et al. · Scientific Reports · 24
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Works count: 65
Citation count: 3,168
H-index: 24
I10-index: 31
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