Author

Steven V. O’Neil

Observed names: O'Neil, S.V., S. V. O'NEIL, S.V. O'Neil, Steven O’Neil, Steven V O'Neil, Steven V. O'Neil

Observed institutions: University of North Carolina at Chapel Hill, Pfizer (United States), Pfizer (United Kingdom), Bristol-Myers Squibb (United States), The Ohio State University, Brandeis University, Procter & Gamble (United States)

ORCID: 0000-0002-0458-2322

Observed ORCID: 0000-0002-0458-2322

OpenAlex ID: A5090701159

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

2018 · Laura A. McAllister, Christopher R. Butler, et al. · Journal of Medicinal Chemistry · 88

Discovery of the Potent and Selective M1 PAM-AgonistN-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

2016 · Jennifer E. Davoren, Che-Wah Lee, et al. · Journal of Medicinal Chemistry · 88

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

2012 · Z.A. Hughes, S.J. Neal, et al. · Neuropharmacology · 87

Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity

2017 · Jennifer E. Davoren, Michelle Garnsey, et al. · Journal of Medicinal Chemistry · 62

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

2006 · Corey R. Hopkins, Steven V. O’Neil, et al. · Bioorganic & Medicinal Chemistry Letters · 50

Design and optimization of selective azaindole amide M1 positive allosteric modulators

2015 · Jennifer E. Davoren, Steven V. O’Neil, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

2006 · Karnail S. Atwal, Steven V. O’Neil, et al. · Bioorganic & Medicinal Chemistry Letters · 42

Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease

2025 · Jamison B. Tuttle, Christophe Allais, et al. · Journal of Medicinal Chemistry · 38

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

2019 · Lei Zhang, Christopher R. Butler, et al. · Journal of Medicinal Chemistry · 37

Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A

1998 · Barry B. Snider, Nha Huu Vo, et al. · The Journal of Organic Chemistry · 37

Advances in the development of novel aggrecanase inhibitors

2010 · Adam M Gilbert, Jack A Bikker, et al. · Expert Opinion on Therapeutic Patents · 32

Synthesis of (±)-Gymnomitrol. Mn(OAc)3-Initiated Free-Radical Cyclization of Alkynyl Ketones

1997 · Steven V. O'Neil, Cheri A. Quickley, et al. · The Journal of Organic Chemistry · 32

Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

2005 · Kofi A. Oppong, Christopher D. Ellis, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

2005 · Steven V. O’Neil, Yili Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 20

Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

2006 · Yili Wang, Steven V. O’Neil, et al. · Bioorganic & Medicinal Chemistry · 19

Studies Toward an Asymmetric Synthesis of CP-263,114 and CP-225,917

2000 · Jean-François Devaux, Steven V. O'Neil, et al. · Collection of Czechoslovak Chemical Communications · 19

The Need for an Incisive Analysis of the Regioselectivity Associated with the Deprotonation of α-Alkoxy and α-Acyloxy Ketones

1999 · Leo A. Paquette, Steven V. O'Neil, et al. · Synlett · 18

Formal synthesis of (±)-upial. Oxidative free-radical cyclization of unsaturated 1,3-cyclohexanediones

1995 · Barry B. Snider, Steven V. O'Neil · Tetrahedron · 18

Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

2006 · Christopher D. Ellis, Kofi A. Oppong, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine

2021 · Jeffrey T. Kohrt, Peter H. Dorff, et al. · Organic Process Research & Development · 16

Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

2006 · David L. Soper, Justin X. Sheville, et al. · Bioorganic & Medicinal Chemistry · 15

Stereochemical Dependence of Base-Catalyzed Cleavage of Cyclic Peroxy Ketals

1994 · Barry B. Snider, Zhongping Shi, et al. · The Journal of Organic Chemistry · 14

Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme

2005 · Michael C. Laufersweiler, Yili Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates

2017 · Antonia F. Stepan, Michelle M. Claffey, et al. · Journal of Medicinal Chemistry · 9

Synthesis of (−)-Acetylsaturejol and (+)-Isoacetylsaturejol

1995 · Barry B. Snider, Steven V. O'Neil · Synthetic Communications · 9

Works count: 38

Citation count: 867

H-index: 18

I10-index: 23