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Wu Yang

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
2021 · Andrew K. Dilger, Kumar B. Pabbisetty, et al. · Journal of Medicinal Chemistry · 111
Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds
2009 · Yang Wu, David Connors, et al. · Toxicology in Vitro · 77
Efficient Synthesis of 2-Aryl-6-chloronicotinamides via PXPd2-Catalyzed Regioselective Suzuki Coupling
2003 · Wu Yang, Yufeng Wang, et al. · Organic Letters · 62
Discovery and Structure−Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists
2009 · Wu Yang, Zheming Ruan, et al. · Journal of Medicinal Chemistry · 58
Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists
2004 · Wu Yang, Yufeng Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 57
A Novel Calcium-Sensing Receptor Antagonist Transiently Stimulates Parathyroid Hormone Secretion in Vivo
2005 · Brian J. Arey, Ramakrishna Seethala, et al. · Endocrinology · 56
Discovery of 4-Aryl-7-Hydroxyindoline-Based P2Y1 Antagonists as Novel Antiplatelet Agents
2014 · Wu Yang, Yufeng Wang, et al. · Journal of Medicinal Chemistry · 48
A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator
2006 · Jianxin Hu, Jiankang Jiang, et al. · Journal of Biological Chemistry · 47
Synthesis and structure–activity relationship of 3-arylbenzoxazines as selective estrogen receptor β agonists
2004 · Wu Yang, Yufeng Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
2020 · Wu Yang, Yufeng Wang, et al. · Journal of Medicinal Chemistry · 28
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
2019 · James R. Corte, Donald J. P. Pinto, et al. · Journal of Medicinal Chemistry · 28
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists
2005 · Ashvinikumar V. Gavai, Roy J. Vaz, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
2017 · James R. Corte, Wu Yang, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Oral Delivery of Highly Lipophilic Poorly Water-Soluble Drugs: Spray-Dried Dispersions to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a P2Y1 Antagonist
2014 · Xue-Qing Chen, Kevin Stefanski, et al. · Journal of Pharmaceutical Sciences · 20
Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent
2014 · Yoon T. Jeon, Wu Yang, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula
2016 · Yueting Li, Yuan Lu, et al. · Molecules · 19
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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
2019 · Charles G. Clark, Karen A. Rossi, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Comparative study of (Asp)7-CHOL-modified liposome prepared using pre-insertion and post-insertion methods for bone targeting in vivo
2016 · Lijing Zhang, Hua Cao, et al. · Journal of drug targeting · 11
High Throughput Screening Identified a Substituted Imidazole as a Novel RANK Pathway-Selective Osteoclastogenesis Inhibitor
2006 · Taosheng Chen, Anita C. Knapp, et al. · Assay and Drug Development Technologies · 11
Differential effects of P2Y1 versus P2Y12 receptor antagonism on thrombosis and bleeding in rabbits
2013 · P. Wong, E. Crain, et al. · European Heart Journal · 5
Enzymatic resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate by Seaprose S
2007 · Iqbal S. Gill, Ellen Kick, et al. · Tetrahedron Asymmetry · 5
Assessing the risk of drug crystallization in vivo
2018 · Stefan Ruepp, Evan Janovitz, et al. · Journal of Pharmacological and Toxicological Methods · 4
Blockers of sulfonylureas receptor 1 subunits may lead to cardiac protection against isoprenaline-induced injury in obese rats
2012 · Yige Bao, Xiaodong Sun, et al. · European Journal of Pharmacology · 4
Determination of Benzidine Using the Analyte Pulse Perturbation Technique in BZ Oscillating Chemical System
2004 · Jinzhang Gao ., Kanjun Sun ., et al. · Pakistan Journal of Biological Sciences · 4
Synthesis and Characterization of 3,4-Bis[3(2-azidoethoxy)furazan-4-yl]furoxan (DAeTF): A Novel Low-Melting Insensitive Energetic Material
2024 · Yang Wu, Yuezhou Liu, et al. · Molecules · 3
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Works count: 34
Citation count: 781
H-index: 16
I10-index: 19
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