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Jan Dobeš

Thymic mimetic cells function beyond self-tolerance
2023 · Tal Givony, Dena Leshkowitz, et al. · Nature · 93
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The emerging family of RORγt+ antigen-presenting cells
2023 · Jakub Abramson, Jan Dobeš, et al. · Nature reviews. Immunology · 81
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Aire-expressing ILC3-like cells in the lymph node display potent APC features
2019 · Tomoyoshi Yamano, Jan Dobeš, et al. · The Journal of Experimental Medicine · 75
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
2022 · Jan Dobeš, Osher Ben-Nun, et al. · Nature Immunology · 63
Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
2020 · Matouš Vobořil, Tomáš Brabec, et al. · Nature Communications · 61
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Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric α-Defensins
2015 · Jan Dobeš, Aleš Neuwirth, et al. · Gastroenterology · 39
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Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
2021 · Yael Goldfarb, Tal Givony, et al. · The Journal of Experimental Medicine · 38
IL18 signaling promotes homing of mature Tregs into the thymus
2020 · Cristina Peligero-Cruz, Tal Givony, et al. · eLife · 38
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HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage–Associated Tumorigenesis
2015 · Lucie Janeckova, Vendula Pospichalova, et al. · Molecular Cancer Research · 34
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum
2023 · Tomáš Brabec, Matouš Vobořil, et al. · Mucosal Immunology · 31
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Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
2023 · Tomáš Brabec, Martin Schwarzer, et al. · The Journal of Experimental Medicine · 29
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Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase
2012 · Aleš Neuwirth, Jan Dobeš, et al. · Cellular Immunology · 27
NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling
2014 · Jitka Stancikova, Michaela Krausova, et al. · Cellular Signalling · 26
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Enteric α-defensins on the verge of intestinal immune tolerance and inflammation
2018 · Dominik Filipp, Tomáš Brabec, et al. · Seminars in Cell and Developmental Biology · 22
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
2023 · Yael Gruper, Anette S. B. Wolff, et al. · Nature · 21
Transcriptional regulation of the thymus master regulatorFoxn1
2022 · Noam Kadouri, Tal Givony, et al. · Science Immunology · 17
A novel conditional Aire allele enables cell‐specific ablation of the immune tolerance regulator Aire
2017 · Jan Dobeš, Frank Edenhofer, et al. · European Journal of Immunology · 10
Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects
2024 · Jan Mašek, Iva Filipovic, et al. · EMBO Molecular Medicine · 6
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Author Correction: Thymic mimetic cells function beyond self-tolerance
2023 · Tal Givony, Dena Leshkowitz, et al. · Nature · 5
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Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
2023 · Tomáš Brabec, Martin Schwarzer, et al. · The Journal of Experimental Medicine · 4
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Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse
2017 · Vitezslav Kriz, Michaela Krausova, et al. · Transgenic Research · 3
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Dietary influence and immune balance: Regulating CD4+ IEL responses and MHCII in the gut
2024 · Jan Dobeš, Tomáš Brabec · Mucosal Immunology · 2
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Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance
2025 · Jiří Březina, Tomáš Brabec, et al. · The Journal of Experimental Medicine · 1
Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance
2025 · Jiří Březina, Tomáš Brabec, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Local and circulating cytotoxic CD4⁺ T cells are early markers of disease activity in pediatric Crohn’s disease
2026 · Veronika Niederlova, Kyle Kimler, et al. · medRxiv
Works count: 39
Citation count: 729
H-index: 16
I10-index: 17
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