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Karl Ludwig Platt

Observed names: K L Platt, K. -L. Platt, K. L. PLATT, K. L. Platt, K. Platt, K.-L. Platt, K.L Platt, K.L. Platt, K.‐L. PLATT, KARL L. PLATT, Karl L Platt, Karl L. PLATT, Karl L. Platt, Karl Platt, Karl-L. Platt, Karl-Ludwig Platt, Karl‐Ludwig Platt, Platt, K.L. (Mainz Univ. (Germany). Inst. fuer Toxikologie)
Observed institutions: Rutgers, The State University of New Jersey, Iowa State University, RTI International, Friedrich-Alexander-Universität Erlangen-Nürnberg, Johannes Gutenberg University Mainz, Purdue University West Lafayette, Ames National Laboratory, University Medical Center of the Johannes Gutenberg University Mainz, Stanford University
OpenAlex ID: A5110014111
Cryopreserved Primary Hepatocytes as a Constantly Available in Vitro Model for the Evaluation of Human and Animal Drug Metabolism and Enzyme Induction*
2000 · JAN G. HENGSTLER, D. UTESCH, et al. · Drug Metabolism Reviews · 275
In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids
1998 · R Rauscher, R Edenharder, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 125
Stereoselective activation of dibenzo[a,l]pyrene to (—)-anti(11R, 12S, 13S, 14R)- and (+)-syn(11S, 12R, 13S, 14R)- 11, 12-diol-13, 14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7
1995 · Sherry L. Ralston, Albrecht Seidel, et al. · Carcinogenesis · 121
Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of glutathione conjugates using high pressure liquid chromatography and field desorption mass spectrometry
1980 · A. Tunek, K.L. Platt, et al. · Chemico-Biological Interactions · 120
Functional heterogeneity of UDP-glucuronyltransferase in rat tissues
1980 · Karl Walter Bock, Ulrich C.V. Clausbruch, et al. · Biochemical Pharmacology · 113
Multiple Activation Pathways of Benzene Leading to Products with Varying Genotoxic Characteristics
1989 · H Glatt, R Padykula, et al. · Environmental Health Perspectives · 110
Microsomal Metabolism of Benzene to Species Irreversibly Binding to Microsomal Protein and Effects of Modifications of This Metabolism
1978 · ANDERS TUNEK, KARL L. PLATT, et al. · Molecular Pharmacology · 109
Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells
2002 · R Edenharder, J.W Sager, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 107
Rat liver cytoplasmic dihydrodiol dehydrogenase. Purification to apparent homogeneity and properties.
1980 · K. Vogel, P. Bentley, et al. · Journal of Biological Chemistry · 104
Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds
1990 · Hansruedi Glatt, Ingrid Gemperlein, et al. · Mutagenesis · 101
Isolation and Characterization of Structurally Novel Antimutagenic Flavonoids from Spinach ( Spinacia oleracea )
2001 · Rudolf Edenharder, Gernot Keller, et al. · Journal of Agricultural and Food Chemistry · 96
Improvement of the correlation of bacterial mutagenicity with carcinogenicity of benzo(a)pyrene and four of its major metabolites by activation with intact liver cells instead of cell homogenate.
1981 · H R Glatt, R Billings, et al. · PubMed · 93
Efficient synthesis of non-K-region trans-dihydrodiols of polycyclic aromatic hydrocarbons from o-quinones and catechols
1983 · Karl L. Platt, Franz Oesch · The Journal of Organic Chemistry · 90
Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction
2000 · Jan G Hengstler, Michael Ringel, et al. · Chemico-Biological Interactions · 83
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo [a,l]pyrene
1994 · Andreas Luch, Hansruedi Glatt, et al. · Carcinogenesis · 83
Drug Metabolizing Capacity of Cryopreserved Human, Rat, and Mouse Liver Parenchymal Cells in Suspension
1999 · Pablo Steinberg, Thomas Fischer, et al. · Drug Metabolism and Disposition · 73
Benzene Metabolism by Reconstituted Cytochromes P450 2B1 and 2E1 and Its Modulation by Cytochrome b5, Microsomal Epoxide Hydrolase, and Glutathione Transferases: Evidence for an Important Role of Microsomal Epoxide Hydrolase in the Formation of Hydroquinone
1993 · R. Snyder, T. Chepiga, et al. · Toxicology and Applied Pharmacology · 71
Genetically engineered V79 chinese hamster cell expression of purified cytochrome P‐450iib1 monooxygenase activity
1989 · K. L. Platt, E. Molitor, et al. · Journal of Biochemical and Molecular Toxicology · 71
The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure–activity relationship study
1997 · R Edenharder, R Rauscher, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 69
Mutagenicity of phenanthrene and phenanthrene K-region derivatives
1979 · M. Bücker, H.R. Glatt, et al. · Mutation Research/Genetic Toxicology · 69
The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
1994 · S L Ralston, H H Lau, et al. · PubMed · 67
An Improved Synthesis oftrans-5,6-Dihydroxy-1,3-cyclohexadiene (trans-1,2-Dihydroxy-1,2-dihydrobenzene)
1977 · Karl L. PLATT, Franz OESCH · Synthesis · 64
Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes
1992 · Dietmar Utesch, Bernd Diener, et al. · Biochemical Pharmacology · 56
Unexpected DNA damage caused by polycyclic aromatic hydrocarbons under standard laboratory conditions
2007 · Karl L. Platt, Susanne Aderhold, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 54
Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells
2010 · K.L. Platt, R. Edenharder, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 51
Works count: 142
Citation count: 3,931
H-index: 35
I10-index: 80
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