Author

Edwin L. Madison

Observed names: Edwin L Madison, Edwin Madison, Edwin L. Madison

Institution: Catalyst Biosciences (United States)

Observed institutions: Louisiana State University, Scripps Research Institute, Box Hill Hospital, Howard Hughes Medical Institute, Dendreon (United States), University of California System, Torrey Pines Institute For Molecular Studies, Catalyst Biosciences (United States), Institute of Molecular Medicine, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston

OpenAlex ID: A5110062275

Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

2003 · Sarah Netzel-Arnett, John D. Hooper, et al. · Cancer and Metastasis Reviews · 289

Serpin-resistant mutants of human tissue-type plasminogen activator

1989 · Edwin L. Madison, Elizabeth J. Goldsmith, et al. · Nature · 244

Proteases as therapeutics

2011 · Charles S. Craik, Michael J. Page, et al. · Biochemical Journal · 238

Catalytic Domain Structures of MT-SP1/Matriptase, a Matrix-degrading Transmembrane Serine Proteinase

2002 · Rainer Friedrich, Pablo Fuentes-Prior, et al. · Journal of Biological Chemistry · 115

Substrate specificity of prostate-specific antigen (PSA)

1998 · Gary S Coombs, Robert C. Bergstrom, et al. · Chemistry & Biology · 101

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Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

1997 · Song-Hua Ke, Gary S. Coombs, et al. · Journal of Biological Chemistry · 93

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CVS‐3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

2004 · Anna V. Galkin, Lynne Mullen, et al. · The Prostate · 88

Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

1993 · Edwin L. Madison, Andreja Kobe, et al. · Science · 84

Substrate Specificity of Tissue Type Plasminogen Activator

1995 · Edwin L. Madison, Gary S. Coombs, et al. · Journal of Biological Chemistry · 78

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Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development

2000 · Zachary Q. Beck, Laurence Hervio, et al. · Virology · 75

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Negative selectivity and the evolution of protease cascades: the specificity of plasmin for peptide and protein substrates

2000 · Laurence S Hervio, Gary S Coombs, et al. · Chemistry & Biology · 60

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Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains

1999 · Gary S. Coombs, Mohan S. Rao, et al. · Journal of Biological Chemistry · 50

Distinguishing the Specificities of Closely Related Proteases

1997 · Song-Hua Ke, Gary S. Coombs, et al. · Journal of Biological Chemistry · 50

Converting Tissue Type Plasminogen Activator into a Zymogen

1997 · Kathy Tachias, Edwin L. Madison · Journal of Biological Chemistry · 49

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Converting Tissue-type Plasminogen Activator into a Zymogen

1996 · Kathy Tachias, Edwin L. Madison · Journal of Biological Chemistry · 47

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Protein Loop Grafting to Construct a Variant of Tissue-type Plasminogen Activator That Binds Platelet Integrin αIIbβ3

1995 · Jeffrey W. Smith, Kathy Tachias, et al. · Journal of Biological Chemistry · 46

Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator

1996 · Gary S. Coombs, Alphonsus T. Dang, et al. · Journal of Biological Chemistry · 44

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Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family

2007 · Otto J. P. Kyrieleis, Robert Huber, et al. · FEBS Journal · 42

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Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors

2003 · Ewa Zeslawska, Uwe Jacob, et al. · Journal of Molecular Biology · 33

Directing Sequence-specific Proteolysis to New Targets

1998 · Gary S. Coombs, Robert C. Bergstrom, et al. · Journal of Biological Chemistry · 27

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Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1

1997 · Kathy Tachias, Edwin L. Madison · Journal of Biological Chemistry · 21

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Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin

1995 · Kathy Tachias, Edwin L. Madison · Journal of Biological Chemistry · 20

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A vector, pSHT, for the expression and secretion of protein domains in mammalian cells

1992 · Edwin L. Madison, Phillip Bird · Gene · 20

Identification of a Hydrophobic Exosite on Tissue Type Plasminogen Activator That Modulates Specificity for Plasminogen

1997 · Song-Hua Ke, Kathy Tachias, et al. · Journal of Biological Chemistry · 18

The Kringle V-Protease Domain Is a Fibrinogen Binding Region within Apo(a)

2001 · Song Xue, Edwin Madison, et al. · Thrombosis and Haemostasis · 14

Works count: 40

Citation count: 2,009

H-index: 21

I10-index: 28