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Gordon Chan

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
1998 · K-D. Fischer, Y-Y. Kong, et al. · Current Biology · 422
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The tyrosine phosphatase Shp2 (PTPN11) in cancer
2008 · Gordon Chan, Demetrios Kalaitzidis, et al. · Cancer and Metastasis Reviews · 387
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations
2005 · M. Golam Mohi, Ifor R. Williams, et al. · Cancer Cell · 276
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Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
2001 · Kerry Tedford, Lars Nitschke, et al. · Nature Immunology · 165
Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation
2009 · Toshiyuki Araki, Gordon Chan, et al. · Proceedings of the National Academy of Sciences · 127
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis
2009 · Gordon Chan, Demetrios Kalaitzidis, et al. · Blood · 121
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery
2004 · Jiwu Wei, Sabine Blum, et al. · Cancer Cell · 109
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Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells
2011 · Gordon Chan, Laurene S. Cheung, et al. · Blood · 102
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells
2010 · Dan Xu, Siying Wang, et al. · Blood · 68
Sphingomyelin‐ceramide turnover in CD28 costimulatory signaling
1995 · Gordon Chan, Atsuo Ochi · European Journal of Immunology · 65
Vav-1 regulates NK T cell development and NK cell cytotoxicity
2001 · Gordon Chan, Thomas Hanke, et al. · European Journal of Immunology · 53
Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis
2013 · Gordon Chan, Shengqing Gu, et al. · Blood · 47
SHP2 is required for BCR-ABL1-induced hematologic neoplasia
2017 · S Gu, A Sayad, et al. · Leukemia · 37
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PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML
2014 · Charles B Goodwin, Xing Jun Li, et al. · Blood · 37
SH2 Domain-Containing Protein-Tyrosine Phosphatases
2010 · Benjamin G. Neel, Gordon Chan, et al. · Elsevier eBooks · 34
Role of PTPN11 (SHP2) in Cancer
2016 · Gordon Chan, Benjamin G. Neel · Springer eBooks · 14
Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice
2014 · Tatiana Usenko, Gordon Chan, et al. · PLoS ONE · 10
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Bad neighbours cause bad blood
2016 · Gordon Chan, Benjamin G. Neel · Nature · 2
The PI3K catalytic subunit p110-delta is a crucial mediator of leukemia-associated mutant PTPN11 -induced GM-CSF hypersensitivity
2012 · Charles B. Goodwin, Rachel L Gearinger, et al. · F1000Research · 2
Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases
2010 · Hui Huang, Zachary Waldon, et al. · Blood · 2
A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.
2007 · Benjamin S. Braun, Laurene S. Cheung, et al. · Blood · 2
Inducible Expression of Leukemia-Associated Shp2 (Ptpn11) Affects Multiple Stages of Hematopoiesis and Causes a Fatal Myeloproliferative Disorder (MPD) in Mice
2007 · Gordon Chan, Demetrios Kalaitzidis, et al. · Blood · 1
HSC-Independent Yolk Sac Progenitors Bear Hallmarks of JMML in a PTPN11D61Y Mouse Model
2014 · Stefan Pasichnyk Tarnawsky, Momoko Yoshimoto, et al. · Blood
Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function
2014 · XingJun Li, Charles Goodwin, et al. · Blood
Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11-Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia
2013 · Charles B Goodwin, Raghuveer Mali, et al. · Blood
Works count: 34
Citation count: 2,083
H-index: 15
I10-index: 17
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