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James N. Leonard

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
1995 · Y. Guz, M. R. Montminy, et al. · Development · 564
A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release
2008 · Zhi-Liang Chu, Chris Carroll, et al. · Endocrinology · 389
Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
1993 · J Leonard, B Peers, et al. · Molecular Endocrinology · 360
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A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
2007 · Zhi-Liang Chu, Robert M. Jones, et al. · Endocrinology · 300
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
2003 · Louise R Howe, Osamu Watanabe, et al. · PubMed · 244
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
1994 · B Peers, J Leonard, et al. · Molecular Endocrinology · 218
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Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.
1994 · H V Petersen, P Serup, et al. · Proceedings of the National Academy of Sciences · 201
GPR119 agonists for the treatment of type 2 diabetes
2009 · Robert M Jones, James N Leonard, et al. · Expert Opinion on Therapeutic Patents · 155
Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119
2008 · Graeme Semple, Beatriz Fioravanti, et al. · Journal of Medicinal Chemistry · 146
N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119
2009 · Zhi-Liang Chu, Chris Carroll, et al. · Molecular Endocrinology · 128
Hormonal Regulation of an Islet-Specific Enhancer in the Pancreatic Homeobox Gene STF-1
1997 · Seema Sharma, Ulupi S. Jhala, et al. · Molecular and Cellular Biology · 108
Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice
2014 · Arthur T. Suckow, David Polidori, et al. · Journal of Biological Chemistry · 96
The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site
1995 · P Serup, H V Petersen, et al. · Biochemical Journal · 90
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Pancreatic Islet Expression of the Homeobox Factor STF-1 Relies on an E-box Motif That Binds USF
1996 · Seema Sharma, James Leonard, et al. · Journal of Biological Chemistry · 88
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Sex hormone-binding globulin receptor signal transduction proceeds via a G protein
1999 · Atif M Nakhla, James Leonard, et al. · Steroids · 86
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control
2011 · Graeme Semple, Albert Ren, et al. · Bioorganic & Medicinal Chemistry Letters · 68
A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates
2019 · Shamina M. Rangwala, Katharine D’Aquino, et al. · Cell Metabolism · 67
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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile
2011 · Graeme Semple, Juerg Lehmann, et al. · Bioorganic & Medicinal Chemistry Letters · 52
Chapter 7 The Emergence of GPR119 Agonists as Anti-Diabetic Agents
2009 · Robert M. Jones, James N. Leonard · Annual reports in medicinal chemistry · 40
Characterization of Cyp2d22, a Novel Cytochrome P450 Expressed in Mouse Mammary Cells
2000 · Niels Blume, James Leonard, et al. · Archives of Biochemistry and Biophysics · 34
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes
2017 · Xuqing Zhang, Chaozhong Cai, et al. · ACS Medicinal Chemistry Letters · 31
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits
2020 · Weimei Sun, Xuqing Zhang, et al. · Journal of Pharmacology and Experimental Therapeutics · 24
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Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists
2017 · Xuqing Zhang, Chaozhong Cai, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes
2018 · Michael P. Winters, Zhihua Sui, et al. · Bioorganic & Medicinal Chemistry Letters · 21
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB 1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity
2018 · Yue-Mei Zhang, Michael N. Greco, et al. · Journal of Medicinal Chemistry · 19
Works count: 40
Citation count: 3,635
H-index: 23
I10-index: 29
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