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John E. Souness

Observed names: JOHN E. SOUNESS, John E Souness, John Souness
OpenAlex ID: A5110111008
Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
2000 · John E. Souness, David Aldous, et al. · Immunopharmacology · 241
Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases
1997 · John E Souness, Sudha Rao · Cellular Signalling · 183
Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
1996 · John E. Souness, Miriam Griffin, et al. · British Journal of Pharmacology · 112
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Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor
1994 · David Raeburn, Stephen L. Underwood, et al. · British Journal of Pharmacology · 107
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Characterization of guinea-pig eosinophil phosphodiesterase activity
1991 · John E. Souness, Caroline M. Carter, et al. · Biochemical Pharmacology · 105
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
2001 · Iain M. McLay, Frank Halley, et al. · Bioorganic & Medicinal Chemistry · 86
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine
1989 · John E. Souness, Roman Brazdil, et al. · British Journal of Pharmacology · 81
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Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors
1992 · John E. Souness, Giles A. Hassall, et al. · Biochemical Pharmacology · 78
An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors
2002 · Jeffrey M. McKenna, Frank Halley, et al. · Journal of Medicinal Chemistry · 75
The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea‐pig peritoneal macrophages
1993 · Nicholas C. Turner, Lorna J. Wood, et al. · British Journal of Pharmacology · 59
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Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone
1994 · John E. Souness, Maria E. Villamil, et al. · British Journal of Pharmacology · 53
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Mapping the kinase domain of janus kinase 3
2003 · Christopher Adams, David J. Aldous, et al. · Bioorganic & Medicinal Chemistry Letters · 48
1 Phosphodiesterase Type IV Inhibitors
1996 · Malcolm N. Palfreyman, John E. Souness · Progress in medicinal chemistry · 46
RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency
2001 · Alan J Collis, Martyn L Foster, et al. · Bioorganic & Medicinal Chemistry Letters · 40
Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: Biochemistry, pharmacology and therapeutic potential in asthma
1993 · David Raeburn, John E. Souness, et al. · Birkhäuser Basel eBooks · 40
Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP‐specific phosphodiesterase
1992 · John E. Souness, Christopher Maslen, et al. · FEBS Letters · 36
Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
1997 · John E. Souness, Clare Houghton, et al. · British Journal of Pharmacology · 33
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Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors
1998 · Wei He, Fu-Chih Huang, et al. · Journal of Medicinal Chemistry · 22
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I
1998 · Christopher Hulme, Kevin Moriarty, et al. · Bioorganic & Medicinal Chemistry Letters · 21
Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles
1998 · Christopher Hulme, Gregory B. Poli, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors
1999 · John E Souness, Clare Houghton, et al. · Biochemical Pharmacology · 16
Orally active indole N-oxide PDE4 inhibitors
1998 · Christopher Hulme, Rose Mathew, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Isoprenaline induction of cAMP-phosphodiesterase in guinea-pig macrophages occurs in the presence, but not in the absence, of the phosphodiesterase type IV inhibitor rolipram
1995 · Maria Kochetkova, Fiona M.F. Burns, et al. · Biochemical Pharmacology · 15
Effect of N6-methyladenosine on fat-cell glucose metabolism
1982 · John E. Souness, John E. Stouffer, et al. · Biochemical Pharmacology · 15
Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams
1998 · Christopher Hulme, Kevin Moriarty, et al. · Bioorganic & Medicinal Chemistry Letters · 13
Works count: 36
Citation count: 1,610
H-index: 20
I10-index: 27
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