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Robert J. Riley

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
2002 · Rupert P. Austin, Patrick Barton, et al. · Drug Metabolism and Disposition · 413
A Unified Model for Predicting Human Hepatic, Metabolic Clearance From in Vitro Intrinsic Clearance Data in Hepatocytes and Microsomes
2005 · Robert J. Riley, D.F. McGinnity, et al. · Drug Metabolism and Disposition · 374
DT-diaphorase and cancer chemotherapy
1992 · Robert J. Riley, Paul Workman · Biochemical Pharmacology · 283
Evaluation of Fresh and Cryopreserved Hepatocytes as in Vitro Drug Metabolism Tools for the Prediction of Metabolic Clearance
2004 · Dermot F. McGinnity, Matthew G. Soars, et al. · Drug Metabolism and Disposition · 274
From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
2007 · Brian Springthorpe, Andrew Bailey, et al. · Bioorganic & Medicinal Chemistry Letters · 237
In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance
2002 · M.G. Soars, B. Burchell, et al. · Journal of Pharmacology and Experimental Therapeutics · 229
The Binding of Drugs to Hepatocytes and Its Relationship to Physicochemical Properties
2004 · Rupert P. Austin, Patrick Barton, et al. · Drug Metabolism and Disposition · 176
The pivotal role of hepatocytes in drug discovery
2006 · Matthew G. Soars, Dermot F. McGinnity, et al. · Chemico-Biological Interactions · 173
Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
2007 · Matthew G. Soars, Ken Grime, et al. · Drug Metabolism and Disposition · 144
Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery
2019 · Adam J. Lucas, Joanne L. Sproston, et al. · Expert Opinion on Drug Discovery · 141
Time-dependent CYP inhibition
2007 · Robert J Riley, Ken Grime, et al. · Expert Opinion on Drug Metabolism & Toxicology · 135
Predictive ADMET studies, the challenges and the opportunities
2004 · Andrew M Davis, Robert J Riley · Current Opinion in Chemical Biology · 133
Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs
2007 · D.F. McGinnity, J. Collington, et al. · Current Drug Metabolism · 128
Automated Definition of the Enzymology of Drug Oxidation by the Major Human Drug Metabolizing Cytochrome P450s
2000 · Dermot F. McGinnity, Alison J. Parker, et al. · Drug Metabolism and Disposition · 120
Development of a Generalized, Quantitative Physicochemical Model of CYP3A4 Inhibition for Use in Early Drug Discovery
2001 · R. J. Riley, A. J. Parker, et al. · Pharmaceutical Research · 114
In vitroanalysis of metabolic predisposition to drug hypersensitivity reactions
1995 · R J Riley, J S Leeder · Clinical & Experimental Immunology · 114
Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
2008 · Stuart W. Paine, Alison J. Parker, et al. · Drug Metabolism and Disposition · 105
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.
2001 · M G Soars, R J Riley, et al. · PubMed · 105
Evaluation of Time-dependent Cytochrome P450 Inhibition Using Cultured Human Hepatocytes
2006 · Dermot F. McGinnity, Amanda J. Berry, et al. · Drug Metabolism and Disposition · 99
Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
2011 · Stuart W. Paine, Karelle Ménochet, et al. · Drug Metabolism and Disposition · 97
The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development
2020 · Paul A. Walker, Stephanie Ryder, et al. · Archives of Toxicology · 91
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Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods
2008 · Kenneth H. Grime, James Bird, et al. · European Journal of Pharmaceutical Sciences · 91
Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
1992 · J S Leeder, R J Riley, et al. · Journal of Pharmacology and Experimental Therapeutics · 91
Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells
2009 · Dermot F. McGinnity, George Zhang, et al. · Drug Metabolism and Disposition · 90
Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug−Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry
2009 · Mathew G. Soars, Peter J. H. Webborn, et al. · Molecular Pharmaceutics · 66
Works count: 90
Citation count: 5,562
H-index: 40
I10-index: 70
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