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Patrick K. Clark

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
2004 · Kalyan Das, Arthur D. Clark,, et al. · Journal of Medicinal Chemistry · 514
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
1996 · Kalyan Das, Jianping Ding, et al. · Journal of Molecular Biology · 188
Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations
1992 · Edward Arnold, Alfredo Jacobo-Molina, et al. · Nature · 185
Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
2004 · Steve Tuske, Stefan G Sarafianos, et al. · Nature Structural & Molecular Biology · 161
Conformation of the HIV-1 Gag Protein in Solution
2006 · Siddhartha A.K. Datta, Joseph E. Curtis, et al. · Journal of Molecular Biology · 144
HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site
2006 · Daniel M. Himmel, Stefan G. Sarafianos, et al. · ACS Chemical Biology · 140
Interactions between HIV-1 Gag Molecules in Solution: An Inositol Phosphate-mediated Switch
2006 · Siddhartha A.K. Datta, Zhuojun Zhao, et al. · Journal of Molecular Biology · 133
HIV-1 Reverse Transcriptase Purified from a Recombinant Strain of Escherichia coli
1990 · P.K. Clark, A.L. Ferris, et al. · AIDS Research and Human Retroviruses · 71
Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?
2006 · Paul L Boyer, Stefan G Sarafianos, et al. · PLoS Pathogens · 66
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
2012 · Paul L. Boyer, Patrick K. Clark, et al. · Journal of Virology · 48
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Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly
2015 · Siddhartha A. K. Datta, Patrick K. Clark, et al. · Journal of Virology · 41
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Solution Properties of Murine Leukemia Virus Gag Protein: Differences from HIV-1 Gag
2011 · Siddhartha A. K. Datta, Xiaobing Zuo, et al. · Journal of Virology · 32
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YADD Mutants of Human Immunodeficiency Virus Type 1 and Moloney Murine Leukemia Virus Reverse Transcriptase Are Resistant to Lamivudine Triphosphate (3TCTP) In Vitro
2001 · Paul L. Boyer, Hong-Qiang Gao, et al. · Journal of Virology · 30
Characterization of the Polymerase and RNase H Activities of Human Foamy Virus Reverse Transcriptase
2004 · Paul L. Boyer, Carolyn R. Stenbak, et al. · Journal of Virology · 29
[15] Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors, and an antibody fab fragment
1995 · Arthur D. Clark, Alfredo Jacobo-Molina, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 29
Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions
1996 · E V Barsov, W E Huber, et al. · Journal of Virology · 28
Purification and protective efficacy of monomeric and modified Yersinia pestis capsular F1-V antigen fusion proteins for vaccination against plague
2007 · Jeremy L. Goodin, David F. Nellis, et al. · Protein Expression and Purification · 25
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
2001 · Elena N. Peletskaya, Paul L. Boyer, et al. · Journal of Virology · 22
Steady state kinetics at high enzyme concentration. The myosin MgATPase.
1985 · D D Hackney, P K Clark · Journal of Biological Chemistry · 21
Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation
2010 · Eun-Gyung Lee, Jacqueline Roy, et al. · Journal of Virology · 15
Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry
2004 · Mamuka Kvaratskhelia, Patrick K Clark, et al. · Virology · 14
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The Basic Loop of the RNase H Domain of MLV RT Is Important Both for RNase H and for Polymerase Activity
2001 · Paul L. Boyer, Hong-Qiang Gao, et al. · Virology · 14
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The catalytic properties of the reverse transcriptase of the lentivirus equine infectious anemia virus
1994 · Tami RUBINEK, Shoshana LOYA, et al. · European Journal of Biochemistry · 14
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Absolute and Relative Configuration of Erythroskyrin
1988 · John A. Beutler, Bruce D. Hilton, et al. · Journal of Natural Products · 14
Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease
2013 · Linda L. Dunn, Paul L. Boyer, et al. · Virology · 7
Works count: 32
Citation count: 1,989
H-index: 19
I10-index: 24
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