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M. Brian Arnold

Observed names: M. B. ARNOLD, M.B. Arnold, M.Brian Arnold, Macklin B. Arnold
OpenAlex ID: A5110145956
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
1998 · Hamideh Zarrinmayeh, Anne M. Nunes, et al. · Journal of Medicinal Chemistry · 152
(3SR,4aRS,6RS,8aRS)-6-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist
1993 · Paul L. Ornstein, M. Brian Arnold, et al. · Journal of Medicinal Chemistry · 121
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells
1999 · Bryan G Johnson, Rebecca A Wright, et al. · Neuropharmacology · 99
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
1998 · Paul L. Ornstein, Thomas J. Bleisch, et al. · Journal of Medicinal Chemistry · 99
[3H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain
2001 · Rebecca A. Wright, M. Brian Arnold, et al. · Journal of Pharmacology and Experimental Therapeutics · 98
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action
1991 · Paul L. Ornstein, Darryle D. Schoepp, et al. · Journal of Medicinal Chemistry · 89
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
2000 · Paul L. Ornstein, Dennis M. Zimmerman, et al. · Journal of Medicinal Chemistry · 77
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
1998 · Paul L. Ornstein, Thomas J. Bleisch, et al. · Journal of Medicinal Chemistry · 71
Binding of [ 3 H](2 S ,1' S ,2' S )-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl)glycine ([ 3 H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes
2000 · Rebecca A. Wright, M. Brian Arnold, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 64
Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution
1996 · Paul L. Ornstein, M. Brian Arnold, et al. · Journal of Medicinal Chemistry · 47
Highly Efficient and Practical Syntheses of Lavendamycin Methyl Ester and Related Novel Quinolindiones
1996 · Mohammad Behforouz, Jalal Haddad, et al. · The Journal of Organic Chemistry · 43
Syntheses of 6-oxodecahydroisoquinoline-3-carboxylates. Useful intermediates for the preparation of conformationally defined excitatory amino acid antagonists
1991 · Paul L. Ornstein, M. Brian Arnold, et al. · The Journal of Organic Chemistry · 43
[3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors
1998 · Paul L. Ornstein, M.Brian Arnold, et al. · Bioorganic & Medicinal Chemistry Letters · 42
6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists
1992 · Paul L. Ornstein, Darryle D. Schoepp, et al. · Journal of Medicinal Chemistry · 38
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
1996 · Paul L. Ornstein, M. Brian Arnold, et al. · Journal of Medicinal Chemistry · 33
[3H]N-2-(4-(N-Benzamido)phenyl)propyl-2- propanesulfonamide: A Novel AMPA Receptor Potentiator and Radioligand
2001 · Hamideh Zarrinmayeh, David Bleakman, et al. · Journal of Medicinal Chemistry · 30
A comprehensive investigation of variations in melting ranges and NMR data of 2,4-dinitrophenylhydrazine derivatives
1998 · Sayyed Faramarz Tayyari, Jeffrey L. Speakman, et al. · Journal of the Chemical Society Perkin Transactions 2 · 29
Tetrazole amino acids as competitive NMDA antagonists
1993 · Paul L. Ornstein, M.Brian Arnold, et al. · Bioorganic & Medicinal Chemistry Letters · 24
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists
1998 · Paul L. Ornstein, M.Brian Arnold, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
2005 · Qing Shi, Paul L. Ornstein, et al. · Bioorganic & Medicinal Chemistry Letters · 21
NMDA antagonist activity of (.+-.)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid residues with the (-)-2R,4S-isomer
1992 · Paul L. Ornstein, Darryle D. Schoepp, et al. · Journal of Medicinal Chemistry · 20
(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist
1995 · Paul L. Ornstein, M. Brian Arnold, et al. · Journal of Medicinal Chemistry · 17
Stereoselective Synthesis of 6-Substituted Decahydroisoquinoline-3-carboxylates: Intermediates for the Preparation of Conformationally Constrained Acidic Amino Acids
1994 · Paul L. Ornstein, Nancy K. Augenstein, et al. · The Journal of Organic Chemistry · 14
Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists
1993 · Paul L. Ornstein, M.Brian Arnold, et al. · Bioorganic & Medicinal Chemistry Letters · 9
Hybrid Tertiary Phosphine Amine and Amide Chelate Ligands: N ‐[2‐(Diphenylphosphino)‐Phenyl]Benzamide and 2‐(Diphenylphosphino)‐ N ‐Phenylbenzamide
1990 · David Hedden, D. Max Roundhill, et al. · Inorganic syntheses · 6
Works count: 33
Citation count: 1,323
H-index: 20
I10-index: 23
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