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Yuan-Fang Wang
Observed name:
Yuan‐Fang Wang
Institution:
Georgia State University
Observed institutions:
University of Debrecen,
Georgia State University,
Purdue University West Lafayette,
National Cancer Institute,
Kumamoto University
OpenAlex ID:
A5110155173
Novel bis -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro
2003
·
Yasuhiro Koh
, Hirotomo Nakata
, et al.
·
Antimicrobial Agents and Chemotherapy
·
371
Kinetic, Stability, and Structural Changes in High-resolution Crystal Structures of HIV-1 Protease with Drug-resistant Mutations L24I, I50V, and G73S
2005
·
Fengling Liu
, Peter I. Boross
, et al.
·
Journal of Molecular Biology
·
80
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
2017
·
Arun K. Ghosh
, Kalapala Venkateswara Rao
, et al.
·
Journal of Medicinal Chemistry
·
76
A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro
2007
·
Masayuki Amano
, Yasuhiro Koh
, et al.
·
Antimicrobial Agents and Chemotherapy
·
69
Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies
2009
·
Arun K. Ghosh
, Sofiya Leshchenko-Yashchuk
, et al.
·
Journal of Medicinal Chemistry
·
65
Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X-ray Studies
2013
·
Arun K. Ghosh
, Garth L. Parham
, et al.
·
Journal of Medicinal Chemistry
·
46
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands
2015
·
Arun K. Ghosh
, Jun Takayama
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
44
Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease
2007
·
Yuan-Fang Wang
, Yunfeng Tie
, et al.
·
Journal of Medicinal Chemistry
·
44
Design, Synthesis, Protein−Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance
2009
·
Arun K. Ghosh
, Sarang Kulkarni
, et al.
·
Journal of Medicinal Chemistry
·
43
Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies
2008
·
Arun K. Ghosh
, Sandra Gemma
, et al.
·
Journal of Medicinal Chemistry
·
40
Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal Structure
2011
·
Arun K. Ghosh
, Bruno D. Chapsal
, et al.
·
Journal of Medicinal Chemistry
·
35
Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors
2011
·
Arun K. Ghosh
, Cuthbert D. Martyr
, et al.
·
ACS Medicinal Chemistry Letters
·
31
Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme–Inhibitor X-ray Structural Studies
2015
·
Arun K. Ghosh
, Xufen Yu
, et al.
·
Journal of Medicinal Chemistry
·
28
Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors
2012
·
Arun K. Ghosh
, Bruno D. Chapsal
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
23
Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation
2016
·
Arun K. Ghosh
, Heather L. Osswald
, et al.
·
Journal of Medicinal Chemistry
·
20
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex
2017
·
Arun K. Ghosh
, Margherita Brindisi
, et al.
·
Bioorganic & Medicinal Chemistry
·
17
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies
2008
·
Arun K. Ghosh
, Sandra Gemma
, et al.
·
Organic & Biomolecular Chemistry
·
16
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Studies
2015
·
Arun K. Ghosh
, Cuthbert D. Martyr
, et al.
·
Journal of Medicinal Chemistry
·
15
Potent Antiviral HIV-1 Protease Inhibitor GRL-02031 Adapts to the Structures of Drug Resistant Mutants with Its P1′-Pyrrolidinone Ring
2012
·
Yu-Chung E. Chang
, XiaXia Yu
, et al.
·
Journal of Medicinal Chemistry
·
14
Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands
2015
·
Arun K. Ghosh
, Cuthbert D. Martyr
, et al.
·
Organic & Biomolecular Chemistry
·
10
Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies
2024
·
Arun K. Ghosh
, Daniel Lee
, et al.
·
Organic & Biomolecular Chemistry
·
2
PDF
Cover Picture: Probing Multidrug‐Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV‐1 Protease Inhibitors (ChemMedChem 11/2010)
2010
·
Arun K. Ghosh
, Chun‐Xiao Xu
, et al.
·
ChemMedChem
PDF
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Works count:
22
Citation count:
1,089
H-index:
16
I10-index:
20
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