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Toshihisa Koga

Observed name: Toshihisa koga
Institution: Otsuka (Japan)
OpenAlex ID: A5110161080
The Uracil Breath Test in the Assessment of Dihydropyrimidine Dehydrogenase Activity: Pharmacokinetic Relationship between Expired 13CO2 and Plasma [2-13C]Dihydrouracil
2006 · Lori K. Mattison, Jeanne Fourie, et al. · Clinical Cancer Research · 77
High performance liquid chromatographic methods for the determination of aripiprazole with ultraviolet detection in rat plasma and brain: Application to the pharmacokinetic study
2005 · Yoshihiko Shimokawa, Hitoshi Akiyama, et al. · Journal of Chromatography B · 75
Mechanism of Hydroxyl Radical Scavenging by Rebamipide: Identification of Mono-hydroxylated Rebamipide as a Major Reaction Product
2004 · Kazushi Sakurai, Hiroyuki Sasabe, et al. · Free Radical Research · 60
Toxicological Evaluation of Acyl Glucuronides of Nonsteroidal Anti-Inflammatory Drugs Using Human Embryonic Kidney 293 Cells Stably Expressing Human UDP-Glucuronosyltransferase and Human Hepatocytes
2010 · Toshihisa Koga, Ryoichi Fujiwara, et al. · Drug Metabolism and Disposition · 49
Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans
2016 · Masateru Miyake, Toshihisa Koga, et al. · European Journal of Pharmaceutical Sciences · 42
N-Glycosylation plays a role in protein folding of human UGT1A9
2009 · Miki Nakajima, Toshihisa Koga, et al. · Biochemical Pharmacology · 40
Physiologically based pharmacokinetic modelling of the three‐step metabolism of pyrimidine using13C‐uracil as anin vivoprobe
2005 · Suminobu Ito, Takeshi Kawamura, et al. · British Journal of Clinical Pharmacology · 26
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Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human
2021 · Hiroyuki Sasabe, Toshihisa Koga, et al. · Xenobiotica · 18
In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole
2021 · Hiroyuki Sasabe, Toshihisa Koga, et al. · Xenobiotica · 16
Liquid chromatography–tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study
2014 · Masayuki Furukawa, Kenichi Miyata, et al. · Archives of Pharmacal Research · 16
Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs
2017 · Masateru Miyake, Satoshi Kondo, et al. · European Journal of Pharmaceutics and Biopharmaceutics · 15
Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Delamanid in Mouse Plasma and Lung
2015 · Yukihiro Hirao, Toshihisa Koga, et al. · American Journal of Analytical Chemistry · 14
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Relationships Among Plasma [2-13c]uracil Concentrations, Breath 13co2 Expiration, and Dihydropyrimidine Dehydrogenase (dpd) Activity in the Liver in Normal and Dpd-deficient Dogs
2004 · Makoto Inada, Yukihiro Hirao, et al. · Drug Metabolism and Disposition · 11
Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop
2012 · Toshiya Minagawa, Kenji Nakano, et al. · The Journal of Toxicological Sciences · 6
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Establishment of an in vitro cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids
2023 · Toshihisa Koga, Kenji Takeuchi, et al. · The Journal of Toxicological Sciences · 3
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Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense
2024 · Toshihisa Koga, Yuko Sahara, et al. · The Journal of Toxicological Sciences · 2
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Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method
2026 · Toshihisa Koga, Yuko Sahara, et al. · The Journal of Toxicological Sciences
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Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human
2021 · Sasabe, Hiroyuki, Toshihisa Koga, et al. · Figshare
Toxicological evaluation of the acyl glucuronide of nonsteroidal anti-inflammatory drugs
2014 · Tsuyoshi Yokoi, Taishi Miyashita, et al. · 한국분석과학회 학술대회
Works count: 20
Citation count: 470
H-index: 12
I10-index: 13
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