Author

Stephen G Pacholok

Observed names: S Pacholok, S. PACHOLOK, S. Pacholok, STEPHEN PACHOLOK, Stephen G. Pacholok, Stephen Pacholok

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Observed institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

OpenAlex ID: A5110182953

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

1989 · J. Gillard, A. W. Ford-Hutchinson, et al. · Canadian Journal of Physiology and Pharmacology · 324

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

1991 · R C Hubbard, G Fells, et al. · Journal of Clinical Investigation · 212

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Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

2000 · William K Hagmann, Charles G Caldwell, et al. · Bioorganic & Medicinal Chemistry Letters · 48

Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

2002 · Christopher A Willoughby, Steven M Hutchins, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

2004 · K Shankaran, Karla L Donnelly, et al. · Bioorganic & Medicinal Chemistry Letters · 36

The Discovery and Biologic Properties of Cephalosporin‐Based Inhibitors of PMN Elastase

1991 · PHILIP DAVIES, B. M. ASHE, et al. · Annals of the New York Academy of Sciences · 26

Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

2004 · K. Shankaran, Karla L. Donnelly, et al. · Bioorganic & Medicinal Chemistry Letters · 23

Inhibition of nitric oxide synthase by benzoxazolones

1997 · K Shankaran, Karla L Donnelly, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

2005 · Ravindra N. Guthikonda, Shrenik K. Shah, et al. · Bioorganic & Medicinal Chemistry Letters · 20

N-Isonicotinoyl-(l)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists

2003 · George A. Doherty, Ginger X. Yang, et al. · Bioorganic & Medicinal Chemistry Letters · 14

Direct Assay of Aα(1–21), a PMN Elastase‐Specific Cleavage Product of Fibrinogen, in the Chimpanzee

1991 · RICHARD A. MUMFORD, HOLLIS WILLIAMS, et al. · Annals of the New York Academy of Sciences · 14

Characterization of Inducible Nitric-oxide Synthase by Cytochrome P-450 Substrates and Inhibitors

1997 · Stephan K. Grant, Barbara G. Green, et al. · Journal of Biological Chemistry · 13

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Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187

1995 · Stephen G. Pacholok, Philip Davies, et al. · Biochemical Pharmacology · 12

Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent

1987 · Robert J. Bonney, Phillip Davies, et al. · Biochemical Pharmacology · 12

Phosphorous acid analogs of L-680,833, a potent monocyclic β-lactam inhibitor of human leukocyte elastase

1995 · Philippe L. Durette, Renee M. Chabin, et al. · Bioorganic & Medicinal Chemistry Letters · 6

Effect of Dialyser Composition and Reuse on Neutrophil Count and Elastase α-1 Proteinase Inhibitor Complex Formation

1992 · K.L. Donovan, S. Pacholok, et al. · The International Journal of Artificial Organs · 5

Leukotrienes and Asthma

1992 · J. Rokach, M. Barth, et al. · Springer eBooks · 4

Evaluation of Pyrrolidin‐2‐imines and 1,3‐Thiazolidin‐2‐imines as Inhibitors of Nitric Oxide Synthase.

2004 · K. Shankaran, Karla L. Donnelly, et al. · ChemInform

Corrigendum to “N-Isonicotinoyl-(l)-4-aminophenylalanine Derivatives as Tight Binding VLA-4 Antagonists”[Bioorg. Med. Chem. Lett. 13 (2003) 1891]

2003 · George A Doherty, Ginger X Yang, et al. · Bioorganic & Medicinal Chemistry Letters

Works count: 19

Citation count: 835

H-index: 12

I10-index: 14