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James V. Heck

Observed names: Heck, J.V., J. V. HECK, J.V. Heck, JAMES V. HECK, James V Heck
OpenAlex ID: A5110620591
Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a
2000 · Maria A. Bednarek, Scott D. Feighner, et al. · Journal of Medicinal Chemistry · 566
Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice
1999 · Bei Zhang, Gino Salituro, et al. · Science · 460
Novel 2,3-Dihydrobenzofuran-2-carboxylic Acids: Highly Potent and Subtype-Selective PPARα Agonists with Potent Hypolipidemic Activity
2005 · Guo Q. Shi, James F. Dropinski, et al. · Journal of Medicinal Chemistry · 101
Discovery of a Potent, Highly Selective, and Orally Efficacious Small-Molecule Activator of the Insulin Receptor
2000 · Kun Liu, Libo Xu, et al. · Journal of Medicinal Chemistry · 89
Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
2005 · Guo Q. Shi, James F. Dropinski, et al. · Journal of Medicinal Chemistry · 79
Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)
1992 · James M. Balkovec, Regina M. Black, et al. · Journal of Medicinal Chemistry · 71
Activation of Insulin Signal Transduction Pathway and Anti-diabetic Activity of Small Molecule Insulin Receptor Activators
2000 · Sajjad A. Qureshi, Victor Ding, et al. · Journal of Biological Chemistry · 68
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Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach
1992 · Robert A. Zambias, Milton L. Hammond, et al. · Journal of Medicinal Chemistry · 60
5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
2003 · Ranjit C. Desai, Wei Han, et al. · Bioorganic & Medicinal Chemistry Letters · 58
(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents
2004 · Hiroo Koyama, Daniel J. Miller, et al. · Journal of Medicinal Chemistry · 57
The synthesis of N-(tetrazol-5-yl)azetidin-2-ones
1984 · Alex Andrus, Beverly Partridge, et al. · Tetrahedron Letters · 54
The synthesis and reactions of 4-carbomethoxy β-sultams
1989 · Michael J. Szymonifka, James V. Heck · Tetrahedron Letters · 45
5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists
2003 · Hiroo Koyama, Julia K Boueres, et al. · Bioorganic & Medicinal Chemistry Letters · 41
A Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist Demonstrates Favorable Effects on Lipid Homeostasis
2004 · Qiu Guo, Soumya P. Sahoo, et al. · Endocrinology · 40
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Reduced Immunotoxicity and Preservation of Antibacterial Activity in a Releasable Side-Chain Carbapenem Antibiotic
1999 · Hugh Rosen, Richard Hajdu, et al. · Science · 37
Nuclear analogs of β-lactam antibiotics I. The synthesis of 6β-amidocyclonocardicins
1981 · J.V. Heck, B.G. Christensen · Tetrahedron Letters · 33
Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: Discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore
1999 · R.R. Wilkening, R.W. Ratcliffe, et al. · Bioorganic & Medicinal Chemistry Letters · 32
Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin.
1998 · Hiranthi Jayasuriya, Gino M. Salituro, et al. · Tetrahedron Letters · 30
Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: Discovery of L-786,392
1999 · R.W. Ratcliffe, R.R. Wilkening, et al. · Bioorganic & Medicinal Chemistry Letters · 29
Total synthesis of L-659,699, a novel inhibitor of cholesterol biosynthesis
1989 · Yuan Ching P. Chiang, Shu Shu Yang, et al. · The Journal of Organic Chemistry · 28
Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists
2003 · Ranjit C. Desai, Dominick F. Gratale, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Synthesis of L-660,631 methyl ester and related compounds
1988 · M.D. Lewis, J.P. Duffy, et al. · Tetrahedron Letters · 24
Synthesis of 3-methylphosphonyl thienamycin and related 3-phosphonyl carbapenems
1984 · Alex Andrus, B.G. Christensen, et al. · Tetrahedron Letters · 22
Absolute configuration of L659,699, a novel inhibitor of cholesterol biosynthesis
1988 · Yuan Ching P. Chiang, Michael N. Chang, et al. · The Journal of Organic Chemistry · 20
Total synthesis of 3-(5-tetrazolyl)carbapenems
1984 · Alex Andrus, James V. Heck, et al. · Journal of the American Chemical Society · 20
Works count: 44
Citation count: 2,178
H-index: 22
I10-index: 29
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