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Author

Lorna H. Mitchell

Observed names: L. H. MITCHELL, L. H. Mitchell, Lorna Mitchell, Mitchell, L.H.
Observed institutions: Commonwealth Scientific and Industrial Research Organisation, University of Auckland, Pfizer (United States), Pfizer (United Kingdom), Epizyme (United States), University of Rochester
OpenAlex ID: A5111383249
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
2019 · Andrew Fedoriw, Satyajit R. Rajapurkar, et al. · Cancer Cell · 357
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
2017 · Allison E. Drew, Oscar Moradei, et al. · Scientific Reports · 151
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
2015 · Lorna H. Mitchell, Allison E. Drew, et al. · ACS Medicinal Chemistry Letters · 145
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution
2006 · Brian D. Palmer, Andrew M. Thompson, et al. · Journal of Medicinal Chemistry · 114
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor
2015 · Lorna H. Mitchell, P. Ann Boriack-Sjodin, et al. · ACS Medicinal Chemistry Letters · 91
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
2018 · Michael J. Thomenius, Jennifer Totman, et al. · PLoS ONE · 62
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An Enantioselective Total Synthesis of (+)- and (−)-Saudin. Determination of the Absolute Configuration
2001 · Robert K. Boeckman,, Maria del Rosario Rico Ferreira, et al. · Journal of the American Chemical Society · 44
A homologous enolate Truce–Smiles rearrangement
2004 · Lorna H. Mitchell, Nicole C. Barvian · Tetrahedron Letters · 40
Identification of a peptide inhibitor for the histone methyltransferase WHSC1
2018 · Michael J. Morrison, P. Ann Boriack-Sjodin, et al. · PLoS ONE · 37
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A Practical Buchwald−Hartwig Amination of 2-Bromopyridines with Volatile Amines
2007 · Jie Jack Li, Zhi Wang, et al. · The Journal of Organic Chemistry · 31
Thyroid receptor agonists for the treatment of androgenetic alopecia
2009 · Jie Jack Li, Lorna H. Mitchell, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists
2022 · Sean Irwin, Craig Karr, et al. · Journal of Biological Chemistry · 21
(1 ,2 )-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production
2007 · Lain-Yen Hu, Daniel Du, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery
2010 · Lorna H. Mitchell, Theodore R. Johnson, et al. · Journal of Medicinal Chemistry · 13
4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production
2009 · Lorna Mitchell, Zhi Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production
2007 · Jennifer A. Van Camp, Lain-Yen Hu, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Studies culminating in the total synthesis and determination of the absolute configuration of (−)-saudin
2011 · Robert K. Boeckman, Maria Rico del Rosario Ferreira, et al. · Tetrahedron · 10
Acid-Promoted Fries Rearrangements of Benzannulated Lactones
1999 · Richard C. Cambie, Lorna H. Mitchell, et al. · Australian Journal of Chemistry · 9
Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer
2017 · Peter G. Smith, Xiaoling Puyang, et al. · Cancer Research · 8
Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production
2009 · Lorna H. Mitchell, Lain-Yen Hu, et al. · Bioorganic & Medicinal Chemistry Letters · 8
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652
2015 · Nathalie Rioux, Lorna H. Mitchell, et al. · Drug Metabolism and Disposition · 7
Documentation of a rare example of an intramolecular 1,2-addition of a trialkylborane to a carbonyl group
2000 · Robert K. Boeckman, Lorna H. Mitchell, et al. · Tetrahedron Letters · 6
Unique 11b‐Substituted Indeno[2,1‐c]quinolin‐6‐one Ring System
2005 · Lorna H. Mitchell, Brian Samas · Synthetic Communications · 4
Modifications of Rings B and C of Podocarpic Acid: Towards the Synthesis of Quassinoids Richard
1998 · C. Cambie, William A. Denny, et al. · Australian Journal of Chemistry · 4
A Synthesis of Triptoquinones D, E, and F from Podocarpic Acid
1998 · Richard C. Cambie, Lorna H. Mitchell, et al. · Australian Journal of Chemistry · 3
Works count: 40
Citation count: 1,231
H-index: 13
I10-index: 17
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