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Shun Higuchi

Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene
2001 · Mizuho Tanabe, Ichiro Ieiri, et al. · Journal of Pharmacology and Experimental Therapeutics · 534
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein
2002 · Yasuo Kurata, Ichiro Ieiri, et al. · Clinical Pharmacology & Therapeutics · 270
Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
2001 · Soichiro Ito, Ichiro Ieiri, et al. · Pharmacogenetics · 234
Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs
2009 · Ichiro Ieiri, Shun Higuchi, et al. · Expert Opinion on Drug Metabolism & Toxicology · 212
Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
2001 · Shigehiro Ohdo, Satoru Koyanagi, et al. · Nature Medicine · 208
Genetic Polymorphism of Cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese Population
1998 · Miyuki Kimura, Ichiro Ieiri, et al. · Therapeutic Drug Monitoring · 204
Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene
2002 · Atsushi Yamauchi, Ichiro Ieiri, et al. · Transplantation · 187
The Effects of Genetic Polymorphisms of CYP2C9 and CYP2C 19 on Phenytoin Metabolism in Japanese Adult Patients with Epilepsy: Studies in Stereoselective Hydroxylation and Population Pharmacokinetics
1998 · Kohsuke Mamiya, Ichiro Ieiri, et al. · Epilepsia · 175
Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans
2008 · Y Yamasaki, I Ieiri, et al. · Clinical Pharmacology & Therapeutics · 170
SLCO1B1 (OATP1B1, an Uptake Transporter) and ABCG2 (BCRP, an Efflux Transporter) Variant Alleles and Pharmacokinetics of Pitavastatin in Healthy Volunteers
2007 · I Ieiri, S Suwannakul, et al. · Clinical Pharmacology & Therapeutics · 163
Polymorphism in Human Organic Cation Transporters and Metformin Action
2008 · Hiroshi Takane, Eriko Shikata, et al. · Pharmacogenomics · 141
Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese Patients
2011 · Tomohiro Sasaki, Hiroshi Takane, et al. · Antimicrobial Agents and Chemotherapy · 139
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects
2000 · H TAKANAGA, A OHNISHI, et al. · Clinical Pharmacology & Therapeutics · 130
Genetic Polymorphism of the CYP2C Subfamily and Excessive Serum Phenytoin Concentration With Central Nervous System Intoxication
2000 · Hideaki Ninomiya, Kohsuke Mamiya, et al. · Therapeutic Drug Monitoring · 119
Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, CYP2C19m1 in exon 5 and CYP2C19m2 in exon 4, in Japanese subjects*
1996 · Ichiro Ieiri, Takahiro Kubota, et al. · Clinical Pharmacology & Therapeutics · 112
Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in Mice
1997 · Shigehiro Ohdo, Tomoko Makinosumi, et al. · Journal of Pharmacology and Experimental Therapeutics · 98
Transforming Growth Factor-β1 Upregulates the Tight Junction and P-glycoprotein of Brain Microvascular Endothelial Cells
2004 · Shinya Dohgu, Atsushi Yamauchi, et al. · Cellular and Molecular Neurobiology · 97
Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy
2003 · Takeshi Hirota, Ichiro Ieiri, et al. · Drug Metabolism and Disposition · 91
Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment
2007 · Masanori Iwase, Kazuo Sonoki, et al. · Atherosclerosis · 79
Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines.
2003 · Mizuho Tanabe, Hiroto Izumi, et al. · PubMed · 79
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder
2005 · Mieko Takimoto, Akinobu Hamada, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 76
Food-drug Interaction of Tacrolimus with Pomelo, Ginger, and Turmeric Juice in Rats
2011 · Kanoko Egashira, Hitoshi Sasaki, et al. · Drug Metabolism and Pharmacokinetics · 71
Methotrexate Chronotherapy is Effective Against Rheumatoid Arthritis
2011 · Hideto To, Hiromichi Yoshimatsu, et al. · Chronobiology International · 71
Catalytic Activity of Three Variants (Ile, Leu, and Thr) at Amino Acid Residue 359 in Human CYP2C9 Gene and Simultaneous Detection Using Single-Strand Conformation Polymorphism Analysis
2000 · Ichiro Ieiri, Hitoshi Tainaka, et al. · Therapeutic Drug Monitoring · 71
CYP2C19 polymorphism effect on phenobarbitone
2000 · K. Mamiya, A. Hadama, et al. · European Journal of Clinical Pharmacology · 68
Works count: 192
Citation count: 6,520
H-index: 41
I10-index: 121
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