Author

Deborah Needham

Observed names: Deborah needham, Needham, Deborah

Observed institution: GlaxoSmithKline (United Kingdom)

OpenAlex ID: A5111450439

Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists

2013 · Panayiotis A. Procopiou, John W. Barrett, et al. · Journal of Medicinal Chemistry · 47

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

2007 · Keith Biggadike, Mohamed Boudjelal, et al. · Journal of Medicinal Chemistry · 41

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

2015 · Juan D. Guzman, Thomas Pesnot, et al. · Journal of Antimicrobial Chemotherapy · 33

Discovery of a Rapidly Metabolized, Long-Acting β2Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

2013 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Journal of Medicinal Chemistry · 23

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

2012 · Panayiotis A. Procopiou, Alison J. Ford, et al. · Bioorganic & Medicinal Chemistry Letters · 21

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

2021 · Christopher R. Wellaway, Ian R. Baldwin, et al. · Journal of Medicinal Chemistry · 17

The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group

2011 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Bioorganic & Medicinal Chemistry · 11

Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols

2008 · Steven P. Keeling, Ian B. Campbell, et al. · Tetrahedron Letters · 11

ChemInform Abstract: Lead Optimization of the N1 Substituent of a Novel Series of Indazole Arylsulfonamides as CCR4 Antagonists and Identification of a Candidate for Clinical Investigation.

2012 · Panayiotis A. Procopiou, Alison J. Ford, et al. · ChemInform · 4

CCDC 906759: Experimental Crystal Structure Determination

2016 · Procopiou, Panayiotis A., Barrett, John W., et al. · The Cambridge Structural Database

CCDC 906760: Experimental Crystal Structure Determination

2016 · Procopiou, Panayiotis A., Barrett, John W., et al. · The Cambridge Structural Database

GW870086: A potent anti-inflammatory glucocorticoid with a novel pharmacological profile

2013 · Stuart Farrow, Iain Uings, et al. · European Respiratory Journal

Works count: 12

Citation count: 208

H-index: 8

I10-index: 8