Author

Bindhu V. Karanam

Observed names: B V Karanam, B. Karanam, B. V. Karanam, B.V. Karanam, Bindhu Karanam

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Observed institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

OpenAlex ID: A5111470558

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

2011 · Margaret Wu, Sheo B. Singh, et al. · Proceedings of the National Academy of Sciences · 147

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

1992 · Styliani H. Vincent, Bindhu V. Karanam, et al. · Archives of Biochemistry and Biophysics · 105

Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity

2001 · Wallace T. Ashton, Rosemary M. Sisco, et al. · Bioorganic & Medicinal Chemistry Letters · 54

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

2007 · Scott B. Hoyt, Clare London, et al. · Bioorganic & Medicinal Chemistry Letters · 46

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

2014 · Harry R. Chobanian, Yan Guo, et al. · ACS Medicinal Chemistry Letters · 41

Imidazopyridines: A novel class of hNav1.7 channel blockers

2008 · Clare London, Scott B. Hoyt, et al. · Bioorganic & Medicinal Chemistry Letters · 37

Trace level quantification of deuterated 17β‐estradiol and estrone in ovariectomized mouse plasma and brain using liquid chromatography/tandem mass spectrometry following dansylation reaction

2004 · Yuan‐Qing Xia, Steve W. Chang, et al. · Rapid Communications in Mass Spectrometry · 37

2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain

2002 · Jonathan R. Young, Song X. Huang, et al. · Bioorganic & Medicinal Chemistry Letters · 37

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

2013 · Ping Liu, Terence G. Hamill, et al. · ACS Medicinal Chemistry Letters · 36

Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

2009 · Sanjeev Kumar, Eugene Y. Tan, et al. · Drug Metabolism and Disposition · 35

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

2013 · Jinqi Liu, Judith N. Gorski, et al. · Obesity · 30

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Metabolism of MK-0524, a Prostaglandin D2 Receptor 1 Antagonist, in Microsomes and Hepatocytes from Preclinical Species and Humans

2006 · Brian J. Dean, Steve Chang, et al. · Drug Metabolism and Disposition · 30

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

2014 · Shuwen He, Qingmei Hong, et al. · ACS Medicinal Chemistry Letters · 27

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

2008 · Cheng Zhu, Alexa R. Hansen, et al. · Bioorganic & Medicinal Chemistry Letters · 26

Mechanistic Studies on the Metabolic Scission of Thiazolidinedione Derivatives to Acyclic Thiols

2005 · Vijay Bhasker G. Reddy, Bindhu V. Karanam, et al. · Chemical Research in Toxicology · 26

Absorption, Metabolism, and Excretion of [14C]MK-0524, a Prostaglandin D2 Receptor Antagonist, in Humans

2007 · Bindhu Karanam, Maria Madeira, et al. · Drug Metabolism and Disposition · 25

A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain

2010 · Sriram Tyagarajan, Prasun K. Chakravarty, et al. · Bioorganic & Medicinal Chemistry Letters · 23

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

2015 · Shrenik K. Shah, Shuwen He, et al. · ACS Medicinal Chemistry Letters · 22

The pharmacokinetics and disposition of MK-0524, a Prostaglandin D2receptor 1 antagonist, in rats, dogs and monkeys

2007 · S. W. Chang, V. Reddy, et al. · Xenobiotica · 22

A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

2013 · Scott B. Hoyt, Clare London, et al. · Bioorganic & Medicinal Chemistry Letters · 21

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

2004 · David Q. Liu, Bindhu V. Karanam, et al. · Drug Metabolism and Disposition · 20

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. I. ROLE OF CYTOCHROME P450, METHYLTRANSFERASES, FLAVIN MONOOXYGENASES, AND ESTERASES

2004 · Bindhu V. Karanam, Cornelis E.C.A. Hop, et al. · Drug Metabolism and Disposition · 20

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

2016 · Whitney L. Petrilli, Scott B. Hoyt, et al. · ACS Medicinal Chemistry Letters · 15

Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

2015 · Jinqi Liu, David G. McLaren, et al. · Pharmacology Research & Perspectives · 12

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

2013 · Shuwen He, Qingmei Hong, et al. · ACS Medicinal Chemistry Letters · 12

Works count: 42

Citation count: 989

H-index: 20

I10-index: 29