Author

Konstanty Wierzba

Observed names: K Wierzba, KONSTANTY WIERZBA, Konstanty WIERZBA

Observed institutions: University of Arizona, Gdańsk University of Technology, Josai University, The University of Kansas Health System, Taiho Pharmaceutical (Japan), Taiho Oncology (United States), University of Kansas Medical Center, RIKEN Advanced Science Institute, University of Arizona Cancer Center, The University of Tokyo, Gdańsk Medical University, Osaka University of Pharmaceutical Sciences

OpenAlex ID: A5111501602

Telomestatin, a Potent Telomerase Inhibitor That Interacts Quite Specifically with the Human Telomeric Intramolecular G-Quadruplex

2002 · Mu-Yong Kim, Hariprasad Vankayalapati, et al. · Journal of the American Chemical Society · 525

Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus

2001 · Kazuo Shin-ya, Konstanty Wierzba, et al. · Journal of the American Chemical Society · 510

Antitumor Activity of a Novel Quinoline Derivative, TAS‐103, with Inhibitory Effects on Topoisomerases I and II

1997 · Teruhiro Utsugi, Kumio Aoyagi, et al. · Japanese Journal of Cancer Research · 118

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.

1990 · YOSHIKAZU SUGIMOTO, TOSHIO OTANI, et al. · The Journal of Antibiotics · 80

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γ-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor

2001 · Yuji Basaki, Lumi Chikahisa, et al. · Angiogenesis · 67

Antitumor agents. 3. Synthesis and biological activity of 4.beta.-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents

1993 · Tadafumi Terada, Katsuhiko Fujimoto, et al. · Journal of Medicinal Chemistry · 64

Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase

2004 · Shingo Yano, Hideki Kazuno, et al. · Bioorganic & Medicinal Chemistry · 53

Identification of Substrate Sequences for Membrane Type-1 Matrix Metalloproteinase Using Bacteriophage Peptide Display Library

1999 · Shuichi Ohkubo, Kazutaka Miyadera, et al. · Biochemical and Biophysical Research Communications · 51

TAT-59, a new triphenylethylene derivative with antitumor activity against hormone-dependent tumors

1990 · Toshiyuki Toko, Yoshikazu Sugimoto, et al. · European Journal of Cancer and Clinical Oncology · 39

TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor alpha and a partial agonist on estrogen receptor beta with low uterotrophic effect.

2005 · Yasuji Yamamoto, Jiro Shibata, et al. · PubMed · 34

Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity

2005 · Kenji Suzuki, Hideko Nagasawa, et al. · Bioorganic & Medicinal Chemistry · 32

TAS-108, a Novel Oral Steroidal Antiestrogenic Agent, Is a Pure Antagonist on Estrogen Receptor α and a Partial Agonist on Estrogen Receptor β with Low Uterotrophic Effect

2005 · Yasuji Yamamoto, Jiro Shibata, et al. · Clinical Cancer Research · 32

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Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents.

1992 · Tadafumi TERADA, Katsuhiko FUJIMOTO, et al. · Chemical and Pharmaceutical Bulletin · 32

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Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: Discovery of novel orally active inhibitors of human thymidine phosphorylase

2004 · Shingo Yano, Hideki Kazuno, et al. · Bioorganic & Medicinal Chemistry · 30

Tubulin as a Major Determinant of Tissue Distribution of Vincristine

1987 · Konstanty Wierzba, Yuichi Sugiyama, et al. · Journal of Pharmaceutical Sciences · 29

New domino reaction. One pot synthesis of 4,7-dihydroxythioaurone derivatives from benzaldehydes and 4-acetyl-2-oxo-benz[1,3]oxathiole

2005 · Marek T. Konieczny, Wojciech Konieczny, et al. · Tetrahedron · 28

Synthesis and Reactivity of 5,8-Dihydroxythioflavanone Derivatives

1999 · Marek T. Konieczny, Barbara Horowska, et al. · The Journal of Organic Chemistry · 27

TAC-101, a benzoic acid derivative, inhibits liver metastasis of human gastrointestinal cancer and prolongs the life-span

1998 · Koji Murakami, Konstanty Wierzba, et al. · Clinical & Experimental Metastasis · 25

A novel cinnamic acid derivative that inhibits Cdc25 dual‐specificity phosphatase activity

2005 · Yoshimi Aoyagi, Norio Masuko, et al. · Cancer Science · 24

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Substrate Phage as a Tool to Identify Novel Substrate Sequences of Proteases

2001 · Shuichi Ohkubo, Kazutaka Miyadera, et al. · Combinatorial Chemistry & High Throughput Screening · 24

Estimation of skin concentrations of topically applied lidocaine at each depth profile

2014 · Takeshi Oshizaka, Keisuke Kikuchi, et al. · International Journal of Pharmaceutics · 23

Proteomics accelerating the identification of the target molecule of bioactive small molecules

2010 · Konstanty Wierzba, Makoto Muroi, et al. · Current Opinion in Chemical Biology · 18

Synthesis of Polyhydroxylated Derivatives of Phenyl Vinyl Sulfone as Structural Analogs of Chalcones

2001 · Marek T. Konieczny, Barbara Horowska, et al. · Synthesis · 17

Specific distribution of TOP-53 to the lung and lung-localized tumor is determined by its interaction with phospholipids.

2000 · M Yoshida, T Kobunai, et al. · PubMed · 16

A Potential Use of a Synthetic Retinoid TAC‐101 as an Orally Active Agent That Blocks Angiogenesis in Liver Metastases of Human Stomach Cancer Cells

2001 · Tsutomu Oikawa, Koji Murakami, et al. · Japanese Journal of Cancer Research · 13

Works count: 45

Citation count: 2,022

H-index: 21

I10-index: 31