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George W. Hardy

Observed names: G. W. HARDY, G. W. Hardy, G.W. Hardy, George Hardy, George W Hardy
OpenAlex ID: A5111545845
Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme
1979 · R. D. Banks, C. C. F. Blake, et al. · Nature · 455
Structural requirements for opioid activity of analogues of the enkephalins
1977 · C. R. Beddell, R. B. Clark, et al. · Proceedings of the Royal Society B Biological Sciences · 111
Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides
1996 · S. George Rahim, Naimisha Trivedi, et al. · Journal of Medicinal Chemistry · 90
Discovery of Further Pyrrolidine trans -Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
2002 · Simon J. F. Macdonald, Michael D. Dowle, et al. · Journal of Medicinal Chemistry · 57
Conformation of two 4'-thio-2'-deoxynucleoside analogs studied by 5000-MHz proton NMR spectroscopy and x-ray crystallography.
1992 · Leo H. Koole, Janez Plavec, et al. · Journal of the American Chemical Society · 53
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
2001 · Simon J.F Macdonald, Michael D Dowle, et al. · Bioorganic & Medicinal Chemistry Letters · 48
Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions
1988 · R.L. Follenfant, G.W. Hardy, et al. · British Journal of Pharmacology · 42
Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity
2007 · Keith Biggadike, Mohamed Boudjelal, et al. · Journal of Medicinal Chemistry · 41
Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics
2007 · Margaret Clackers, Diane M. Coe, et al. · Bioorganic & Medicinal Chemistry Letters · 30
β-Anomer selectivity in 2′-deoxynucleoside synthesis: A novel approach using an acyl carbamate directing group
1994 · Robert J. Young, Sue Shaw-Ponter, et al. · Tetrahedron Letters · 26
Peripherally acting enkephalin analogs. 2. Polar tri- and tetrapeptides
1989 · George W. Hardy, Lawrence A. Lowe, et al. · Journal of Medicinal Chemistry · 24
Peripherally acting enkephalin analogs. 1. Polar pentapeptides
1988 · George W. Hardy, Lawrence A. Lowe, et al. · Journal of Medicinal Chemistry · 24
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
2016 · Stuart T. Onions, Kazuhiro Ito, et al. · Journal of Medicinal Chemistry · 19
Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease
2002 · Martin J. Slater, David M. Andrews, et al. · Bioorganic & Medicinal Chemistry Letters · 17
BW A575C, a chemically novel agent with angiotensin converting enzyme inhibitor and β‐adrenoceptor‐blocking properties
1987 · G. Allan, D. Cambridge, et al. · British Journal of Pharmacology · 16
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Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine
1996 · Sue Shaw-Ponter, Gail Mills, et al. · Tetrahedron Letters · 15
Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams
2001 · Simon J.F Macdonald, Michael D Dowle, et al. · Bioorganic & Medicinal Chemistry Letters · 14
A hybrid gene to express protein epitopes from both sporozoite and merozoite surface antigens of Plasmodium falciparum
1988 · A. A. Holder, M. J. Lockyer, et al. · Parasitology · 13
Synthesis of A575C, a combined angiotensin converting enzyme inhibitor-beta adrenoceptor antagonist
1988 · George W. Hardy, Donald Bull, et al. · Tetrahedron Letters · 12
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
2009 · Keith Biggadike, Matilde Caivano, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols
2008 · Steven P. Keeling, Ian B. Campbell, et al. · Tetrahedron Letters · 11
Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase
1999 · Paul S. Jones, Paul W. Smith, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Efficient Syntheses of ( E )-5-(2-Bromovinyl)-2′-deoxy-4-thiouridine; A Nucleoside Analogue with Potent Biological Activity
1998 · I. Basnak, G. P. Otter, et al. · Nucleosides and Nucleotides · 9
Amino-acids and peptides. Part 42. Synthesis of a protected docosa peptide having the sequence of mast-cell degranulating peptide
1979 · Dilys M. Bratby, Susan Coyle, et al. · Journal of the Chemical Society Perkin Transactions 1 · 9
Primary structure of 3-phosphoglycerate kinase from horse muscle. I. Purification of cyanogen bromide peptides and amino acid sequence of peptide CB5 (104 residues).
1981 · G.W. Hardy, A. Darbre, et al. · Journal of Biological Chemistry · 7
Works count: 38
Citation count: 1,173
H-index: 15
I10-index: 22
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