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Anton H Bom

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).
2002 · Anton Bom, Mark Bradley, et al. · Angewandte Chemie International Edition · 457
Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure−Activity Relationships
2002 · Julia M. Adam, D. Jonathan Bennett, et al. · Journal of Medicinal Chemistry · 237
A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host
2002 · Anton Bom, Mark Bradley, et al. · Angewandte Chemie · 226
Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970
2003 · Ola Epemolu, Anton Bom, et al. · Anesthesiology · 154
Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey
2006 · H.D. de Boer, J van Egmond, et al. · British Journal of Anaesthesia · 150
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Preclinical pharmacology of sugammadex
2009 · Anton Bom, Frank Hope, et al. · Journal of Critical Care · 127
Regional wall motion from radiopaque markers after intravenous and intracoronary injections of nifedipine.
1981 · P W Serruys, R W Brower, et al. · Circulation · 97
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Safety of sugammadex for reversal of neuromuscular block
2019 · GHM Honing, CH Martini, et al. · Expert Opinion on Drug Safety · 63
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Reversal of Profound Rocuronium Neuromuscular Blockade by Sugammadex in Anesthetized Rhesus Monkeys
2006 · Hans D. de Boer, Jan van Egmond, et al. · Anesthesiology · 62
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Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys
2005 · H.D. de Boer, J van Egmond, et al. · British Journal of Anaesthesia · 58
5‐Hydroxytryptamine‐induced tachycardia in the pig: possible involvement of a new type of 5‐hydroxytryptamine receptor
1988 · A.H. Bom, D.J. Duncker, et al. · British Journal of Pharmacology · 56
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Effects of MDL 72222 and methiothepin on carotid vascular responses to 5-hydroxytryptamine in the pig: Evidence for the presence of ?5-hydroxytryptamine1-like? receptors
1986 · Pramod R. Saxena, Dirk J. Duncker, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 48
Selective relaxant binding agents for reversal of neuromuscular blockade
2007 · A BOM, O EPEMOLU, et al. · Current Opinion in Pharmacology · 38
Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT1‐like receptors
1989 · Anton H. Bom, Pieter D. Verdouw, et al. · British Journal of Pharmacology · 27
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Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats
2011 · Lonneke M. Staals, Hans D. de Boer, et al. · Journal of Anesthesia · 25
Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation †
2006 · H.D. de Boer, J. van Egmond, et al. · British Journal of Anaesthesia · 22
Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis
1999 · D.R Barn, A Bom, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Characterization of 5-hydroxytryptamine receptors in the cranial vasculature
1989 · Pramod R Saxena, Anton H Bom, et al. · Cephalalgia · 21
Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties
2006 · Ronald Palin, Anton Bom, et al. · Bioorganic & Medicinal Chemistry · 18
The 5-HT1-like receptor mediating reduction of porcine carotid arteriovenous shunting by RU 24969 is not related to either the 5-HT1A or the 5-HT1B subtype
1989 · Anton H. Bom, Carlos M. Villalón, et al. · European Journal of Pharmacology · 18
Effects of 5-Hydroxytryptamine on Capillary and Arteriovenous Anastomotic Blood Flow in the Human Hand and Forearm and in the Pig Hind Leg
1991 · Gerard J. Blauw, Anton H. Bom, et al. · Journal of Cardiovascular Pharmacology · 15
Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptor
1990 · Carlos M. Villalón, Anton H. Bom, et al. · European Journal of Pharmacology · 15
Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT1‐like or 5‐HT2 receptors
1989 · Anton H. Bom, Jan P.C. Heiligers, et al. · British Journal of Pharmacology · 15
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Org 25969 causes selective reversal of neuromuscular blockade induced by steroidal NMBs in the mouse hemi-diaphragm preparation
2001 · S. Miller, A. Bom · European Journal of Anaesthesiology · 14
Chemical chelation as a novel method of NMB reversal - discovery of Org 25969
2001 · A. Bom, K. Cameron, et al. · European Journal of Anaesthesiology · 14
Works count: 62
Citation count: 2,114
H-index: 18
I10-index: 31
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