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Lyann Sim

Human Intestinal Maltase–Glucoamylase: Crystal Structure of the N-Terminal Catalytic Subunit and Basis of Inhibition and Substrate Specificity
2007 · Lyann Sim, Roberto Quezada-Calvillo, et al. · Journal of Molecular Biology · 367
Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains
2010 · Lyann Sim, Carly Willemsma, et al. · Journal of Biological Chemistry · 251
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New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from Salacia reticulata
2009 · Lyann Sim, Kumarasamy Jayakanthan, et al. · Biochemistry · 198
An enzymatic pathway in the human gut microbiome that converts A to universal O type blood
2019 · Peter Rahfeld, Lyann Sim, et al. · Nature Microbiology · 110
Total Syntheses of Casuarine and Its 6‐O‐α‐Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families
2009 · Francesca Cardona, Camilla Parmeggiani, et al. · Chemistry - A European Journal · 108
Luminal Starch Substrate “Brake” on Maltase-Glucoamylase Activity Is Located within the Glucoamylase Subunit3
2008 · Roberto Quezada-Calvillo, Lyann Sim, et al. · Journal of Nutrition · 105
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase
2011 · Kyra Jones, Lyann Sim, et al. · Bioorganic & Medicinal Chemistry · 90
Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives
2006 · Elena J. Rossi, Lyann Sim, et al. · FEBS Journal · 88
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Evidence of native starch degradation with human small intestinal maltase‐glucoamylase (recombinant)
2007 · Zihua Ao, Roberto Quezada-Calvillo, et al. · FEBS Letters · 71
Crystal Structure of the Chlamydomonas Starch Debranching Enzyme Isoamylase ISA1 Reveals Insights into the Mechanism of Branch Trimming and Complex Assembly
2014 · Lyann Sim, Sophie R. Beeren, et al. · Journal of Biological Chemistry · 70
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Unexpected High Digestion Rate of Cooked Starch by the Ct-Maltase-Glucoamylase Small Intestine Mucosal α-Glucosidase Subunit
2012 · Amy Hui-Mei Lin, Buford L. Nichols, et al. · PLoS ONE · 55
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A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans
2018 · Ting Du, Nakita Buenbrazo, et al. · Cell chemical biology · 53
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New Synthetic Routes to Chain-Extended Selenium, Sulfur, and Nitrogen Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol and their Inhibitory Activities against Recombinant Human Maltase Glucoamylase
2007 · Hui Liu, Ravindranath Nasi, et al. · The Journal of Organic Chemistry · 48
Studies Directed toward the Stereochemical Structure Determination of the Naturally Occurring Glucosidase Inhibitor, Kotalanol: Synthesis and Inhibitory Activities against Human Maltase Glucoamylase of Seven-Carbon, Chain-Extended Homologues of Salacinol
2008 · Ravindranath Nasi, Brian O. Patrick, et al. · The Journal of Organic Chemistry · 46
A New Class of Glucosidase Inhibitor: Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension
2006 · Hui Liu, Lyann Sim, et al. · The Journal of Organic Chemistry · 40
Oligosaccharide and Substrate Binding in the Starch Debranching Enzyme Barley Limit Dextrinase
2015 · Marie S. Møller, Michael S. Windahl, et al. · Journal of Molecular Biology · 36
Synthesis of S-alkylated sulfonium-ions and their glucosidase inhibitory activities against recombinant human maltase glucoamylase
2007 · Sankar Mohan, Lyann Sim, et al. · Carbohydrate Research · 35
New Chain-Extended Analogues of Salacinol and Blintol and Their Glycosidase Inhibitory Activities. Mapping the Active-Site Requirements of Human Maltase Glucoamylase
2006 · Ravindranath Nasi, Lyann Sim, et al. · The Journal of Organic Chemistry · 35
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers
2021 · Erika M. J. Siren, Haiming D. Luo, et al. · Nature Biomedical Engineering · 34
An alternative broad-specificity pathway for glycan breakdown in bacteria
2024 · Seyed Amirhossein Nasseri, Aleksander C. Lazarski, et al. · Nature · 31
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Convergent Evolution of Polysaccharide Debranching Defines a Common Mechanism for Starch Accumulation in Cyanobacteria and Plants
2013 · Ugo Cenci, Malika Chabi, et al. · The Plant Cell · 31
7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins
2021 · Andreas Geissner, Lars Baumann, et al. · ACS Central Science · 30
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X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid
2017 · Christian Lizak, Liam J. Worrall, et al. · Scientific Reports · 21
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A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins
2023 · Jacob F. Wardman, Lyann Sim, et al. · Nature Chemical Biology · 18
Structural and biochemical characterization of the N ‐terminal domain of flocculin L g‐ F lo1p from S accharomyces pastorianus reveals a unique specificity for phosphorylated mannose
2013 · Lyann Sim, Magnus Groes, et al. · FEBS Journal · 16
Works count: 66
Citation count: 2,111
H-index: 22
I10-index: 32
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