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Peter M. Lockey

Observed names: P M Lockey, P. LOCKEY, P. Lockey, P. M. LOCKEY, P. M. Lockey, PM Lockey, Peter Lockey
OpenAlex ID: A5111654525
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator
2013 · Ioannis Zalachoras, René Houtman, et al. · Proceedings of the National Academy of Sciences · 120
Histone Deacetylase Inhibitor Trichostatin A Represses Estrogen Receptor α-Dependent Transcription and Promotes Proteasomal Degradation of Cyclin D1 in Human Breast Carcinoma Cell Lines
2004 · John Patrick Alao, Eric W-F. Lam, et al. · Clinical Cancer Research · 113
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action
2014 · Olivier René, Benjamin P. Fauber, et al. · ACS Medicinal Chemistry Letters · 85
A Virtual Screening Approach to Finding Novel and Potent Antagonists at the Melanin-Concentrating Hormone 1 Receptor
2004 · David E. Clark, Christopher Higgs, et al. · Journal of Medicinal Chemistry · 79
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc
2013 · Benjamin P. Fauber, Gladys de Leon Boenig, et al. · Bioorganic & Medicinal Chemistry Letters · 67
Discovery of 1-{4-[3-Fluoro-4-((3 S ,6 R )-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist
2015 · Benjamin P. Fauber, Olivier René, et al. · Journal of Medicinal Chemistry · 65
BGC20‐1531, a novel, potent and selective prostanoid EP4receptor antagonist: a putative new treatment for migraine headache
2009 · KA Maubach, RJ Davis, et al. · British Journal of Pharmacology · 59
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Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists
2014 · Benjamin P. Fauber, Olivier René, et al. · Bioorganic & Medicinal Chemistry Letters · 55
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer
2015 · Helen E. Colley, Munitta Muthana, et al. · Journal of Medicinal Chemistry · 52
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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity
2008 · Robin D. Clark, Nicholas C. Ray, et al. · Bioorganic & Medicinal Chemistry Letters · 50
Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists
2004 · Rosa Arienzo, David E Clark, et al. · Bioorganic & Medicinal Chemistry Letters · 42
A reversed sulfonamide series of selective RORc inverse agonists
2014 · Monique B. van Niel, Benjamin P. Fauber, et al. · Bioorganic & Medicinal Chemistry Letters · 36
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
2006 · Steve Price, Walter Bordogna, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists
2010 · Sue Cramp, Hazel J. Dyke, et al. · Bioorganic & Medicinal Chemistry Letters · 30
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
2006 · Steve Price, Walter Bordogna, et al. · Bioorganic & Medicinal Chemistry Letters · 30
Identification of tertiary sulfonamides as RORc inverse agonists
2014 · Benjamin P. Fauber, Olivier René, et al. · Bioorganic & Medicinal Chemistry Letters · 29
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
2012 · Hazel J. Hunt, Nicholas C. Ray, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
2007 · Nicholas C. Ray, Robin D. Clark, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Quinazoline and benzimidazole MCH-1R antagonists
2006 · Rosa Arienzo, Sue Cramp, et al. · Bioorganic & Medicinal Chemistry Letters · 24
New non peptidic C5a receptor antagonists
1997 · Peter C. Astles, Thomas J. Brown, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies
2016 · David E. Clark, Bohdan Waszkowycz, et al. · Bioorganic & Medicinal Chemistry Letters · 18
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Comparison of the mitogenic activity of angiotensin II and serotonin on porcine arterial smooth muscle cells
1991 · David P. Parrott, Peter M. Lockey, et al. · Atherosclerosis · 17
Critical period for a teratogenic VLA‐4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non‐teratogenic VLA‐4 antagonists
2004 · F. Crofts, S. Rohatagi, et al. · Birth Defects Research Part B Developmental and Reproductive Toxicology · 16
Identification of a non peptidic RANTES antagonist
1998 · Colin Bright, Thomas J. Brown, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Selective Endothelin A Receptor Antagonists. 4. Discovery and Structure−Activity Relationships of Stilbene Acid and Alcohol Derivatives
1998 · Peter C. Astles, Thomas J. Brown, et al. · Journal of Medicinal Chemistry · 13
Works count: 45
Citation count: 1,209
H-index: 20
I10-index: 30
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