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Wengen Wu

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
2016 · Marian C Okondo, Darren C Johnson, et al. · Nature Chemical Biology · 294
Quantitation of fibroblast activation protein (FAP)‐specific protease activity in mouse, baboon and human fluids and organs
2013 · Fiona M. Keane, Tsun-Wen Yao, et al. · FEBS Open Bio · 134
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An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis
2018 · Ben Roediger, Quintin Lee, et al. · Cell · 121
Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase
2013 · Sarah E. Poplawski, Jack H. Lai, et al. · Journal of Medicinal Chemistry · 117
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
2014 · Daniel A Bachovchin, Luke W Koblan, et al. · Nature Chemical Biology · 76
Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors
2011 · Lawrence J. Milo, Jack H. Lai, et al. · Journal of Medicinal Chemistry · 76
Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety
2008 · Beth A. Connolly, David G. Sanford, et al. · Journal of Medicinal Chemistry · 72
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
2016 · Andrew L. Coppage, Kathryn R. Heard, et al. · PLoS ONE · 71
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Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity
2015 · Tatos Akopian, Olga Kandror, et al. · Journal of Biological Chemistry · 59
Preclinical Development of PNT6555, a Boronic Acid–Based, Fibroblast Activation Protein-α (FAP)–Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors
2023 · Sarah E. Poplawski, Robin M. Hallett, et al. · Journal of Nuclear Medicine · 41
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Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
2003 · Dawei Ma, Wengen Wu, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma
2021 · James M. Henderson, Michelle S. W. Xiang, et al. · Cancers · 27
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Sphingosine Kinase 1 Isoform-Specific Interactions in Breast Cancer
2014 · Daniel Yagoub, Marc R. Wilkins, et al. · Molecular Endocrinology · 24
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Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice
2018 · Brandon L. Panaro, Andrew L. Coppage, et al. · Molecular Metabolism · 22
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A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates
2013 · Kathryn R. Heard, Wengen Wu, et al. · Journal of Medicinal Chemistry · 22
Facile synthesis of (+)-α-allokainic acid via Pd-catalyzed hydrogenolysis of allyl acetate derived from trans-4-hydroxy-l-proline
2001 · Dawei Ma, Wengen Wu, et al. · Tetrahedron Letters · 20
A Pan-Inhibitor of DASH Family Enzymes Induces Immune-mediated Regression of Murine Sarcoma and Is a Potent Adjuvant to Dendritic Cell Vaccination and Adoptive T-cell Therapy
2013 · Brynn B. Duncan, Steven L. Highfill, et al. · Journal of Immunotherapy · 16
Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors: Amino-Lactam boroAlanines
2007 · Jack H. Lai, Wengen Wu, et al. · Journal of Medicinal Chemistry · 16
Synthesis and Structural Investigation of Internally Coordinated α-Amidoboronic Acids
2005 · Jack H. Lai, Yuxin Liu, et al. · The Journal of Organic Chemistry · 14
4-Substituted boro-proline dipeptides: Synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
2012 · Wengen Wu, Yuxin Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 13
Autochelation in Dipeptide Boronic Acids: pH-Dependent Structures and Equilibria of Asp-boroPro and His-boroPro by NMR Spectroscopy
2005 · James L. Sudmeier, Yuhong Zhou, et al. · Journal of the American Chemical Society · 13
Synthesis of (2S,1′R,2′R,3′R)-2-(2′,3′-Dicarboxycyclopropyl)-glycine via the Stereochemically Controlled Cyclopropanation of (S)-Glyceraldehyde Acetonide-Derived Enones
2000 · Dawei Ma, Yeyu Cao, et al. · Tetrahedron · 13
A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines
2014 · Renee N. Donahue, Brynn B. Duncan, et al. · Vaccine · 12
Activation mechanism and structural assembly of the Mycobacterium tuberculosis ClpP1P2 protease and its associated ATPases
2026 · Katharina Weinhäupl, Tatos Akopian, et al. · Cell Reports · 7
Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells
2025 · Wa Xian, Shan Wang, et al. · Gastroenterology · 7
Works count: 32
Citation count: 1,331
H-index: 16
I10-index: 23
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