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Mark L. Cunningham

Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani
2004 · Susan Wyllie, Mark L. Cunningham, et al. · Journal of Biological Chemistry · 306
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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
1999 · Charles S Bond, Yihong Zhang, et al. · Structure · 208
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Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival
1998 · Jorge Tovar, Mark L. Cunningham, et al. · Proceedings of the National Academy of Sciences · 166
Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials
1995 · Mark L. Cunningham, Alan H. Fairlamb · European Journal of Biochemistry · 132
Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin
2001 · Mark L. Cunningham, Richard G. Titus, et al. · Science · 122
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
2012 · Leslie W. Tari, Michael Trzoss, et al. · Bioorganic & Medicinal Chemistry Letters · 121
Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents
2013 · Leslie W. Tari, Xiaoming Li, et al. · PLoS ONE · 105
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Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
1994 · Mark L. CUNNINGHAM, Marketa J. J. M. ZVELEBIL, et al. · European Journal of Biochemistry · 104
Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy
2001 · Mark L. Cunningham, Stephen M. Beverley · Molecular and Biochemical Parasitology · 101
Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism
1992 · Alan H. Fairlamb, Nicola S. Carter, et al. · Molecular and Biochemical Parasitology · 100
The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution
1996 · Yihong Zhang, Charles S. Bond, et al. · Protein Science · 99
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity
2012 · Micheal Trzoss, Daniel C. Bensen, et al. · Bioorganic & Medicinal Chemistry Letters · 80
Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
2014 · Thanh Lam, Mark T. Hilgers, et al. · Journal of Medicinal Chemistry · 72
The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)
1999 · Craig Lemley, Shaofeng Yan, et al. · Molecular and Biochemical Parasitology · 71
Site-Directed Mutagenesis of the Redox-Active Cysteines of Trypanosoma cruzi Trypanothione Reductase
1995 · Adolfo Borges, Mark L. Cunningham, et al. · European Journal of Biochemistry · 70
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines
2011 · Xiaoming Li, Mark Hilgers, et al. · Bioorganic & Medicinal Chemistry Letters · 63
Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones
1997 · Carlos L. Zani, Egler Chiari, et al. · Bioorganic & Medicinal Chemistry · 57
Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design
2013 · Min Teng, Mark T. Hilgers, et al. · Journal of Medicinal Chemistry · 50
Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay
2013 · Mark L. Cunningham, Bryan P. Kwan, et al. · SLAS DISCOVERY · 39
Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus
2014 · Mary E Hensler, Kyoung Hwa Jang, et al. · The Journal of Antibiotics · 37
Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators
2018 · Jason R. Clapper, Cassandra L. Henry, et al. · Journal of Pharmacology and Experimental Therapeutics · 32
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Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major
2002 · Lon-Fye Lye, Mark L. Cunningham, et al. · Journal of Biological Chemistry · 31
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Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification
2001 · Susan M. Sunkin, Paul McDonagh, et al. · Molecular and Biochemical Parasitology · 10
Trypanosoma cruzi Trypanothione Reductase Crystallization, Unit Cell Dimensions and Structure Solution
1993 · Yihong Zhang, Susan Bailey, et al. · Journal of Molecular Biology · 8
The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase
2011 · Mark L. Cunningham · Methods in molecular biology · 1
Works count: 25
Citation count: 2,185
H-index: 22
I10-index: 23
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