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Mikel P. Moyer

Observed names: Mikel Moyer, Mikel P Moyer, Mikel P. Moyer
OpenAlex ID: A5111682318
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
2011 · Scott R. Daigle, Edward J. Olhava, et al. · Cancer Cell · 933
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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
2013 · Sarah K. Knutson, Natalie M. Warholic, et al. · Proceedings of the National Academy of Sciences · 810
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
2012 · Sarah K Knutson, Tim J Wigle, et al. · Nature Chemical Biology · 791
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
2013 · Scott R. Daigle, Edward J. Olhava, et al. · Blood · 737
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
2015 · Elayne Chan-Penebre, Kristy G Kuplast, et al. · Nature Chemical Biology · 573
Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2 -Mutant Non-Hodgkin Lymphoma
2014 · Sarah K. Knutson, Satoshi Kawano, et al. · Molecular Cancer Therapeutics · 547
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
2019 · Andrew Fedoriw, Satyajit R. Rajapurkar, et al. · Cancer Cell · 357
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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
2016 · Kevin W. Kuntz, John E. Campbell, et al. · Journal of Medicinal Chemistry · 186
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
2015 · Kenneth W. Duncan, Nathalie Rioux, et al. · ACS Medicinal Chemistry Letters · 177
Intramolecular nitrogen-hydrogen, oxygen-hydrogen and sulfur-hydrogen insertion reactions. Synthesis of heterocycles from .alpha.-diazo .beta.-keto esters
1985 · Mikel P. Moyer, Paul L. Feldman, et al. · The Journal of Organic Chemistry · 159
A687V EZH2 is a gain‐of‐function mutation found in lymphoma patients
2012 · Christina R. Majer, Lei Jin, et al. · FEBS Letters · 154
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
2017 · Allison E. Drew, Oscar Moradei, et al. · Scientific Reports · 151
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Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
2012 · Aravind Basavapathruni, Lei Jin, et al. · Chemical Biology & Drug Design · 147
Metal-halogen exchange of bromoindoles. A route to substituted indoles
1986 · Mikel P. Moyer, John F. Shiurba, et al. · The Journal of Organic Chemistry · 147
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
2015 · Lorna H. Mitchell, Allison E. Drew, et al. · ACS Medicinal Chemistry Letters · 145
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
2015 · John E. Campbell, Kevin W. Kuntz, et al. · ACS Medicinal Chemistry Letters · 131
DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells
2014 · Christine R. Klaus, Dorothy Iwanowicz, et al. · Journal of Pharmacology and Experimental Therapeutics · 131
Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis
2011 · Robert A. Copeland, Aravind Basavapathruni, et al. · Analytical Biochemistry · 119
Nonclinical pharmacokinetics and metabolism of EPZ‐5676, a novel DOT1L histone methyltransferase inhibitor
2014 · Aravind Basavapathruni, Edward J. Olhava, et al. · Biopharmaceutics & Drug Disposition · 81
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
2014 · Sarah K. Knutson, Natalie M. Warholic, et al. · PLoS ONE · 71
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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
2018 · Michael J. Thomenius, Jennifer Totman, et al. · PLoS ONE · 62
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Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates
2015 · P. Ann Boriack-Sjodin, Lei Jin, et al. · ACS Chemical Biology · 45
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening
2015 · Tim J. Wigle, Kerren K. Swinger, et al. · SLAS DISCOVERY · 38
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Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2
2014 · Brooke M. Swalm, Sarah K. Knutson, et al. · ACS Chemical Biology · 35
Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human
2015 · Nigel J. Waters, Sherri A. Smith, et al. · Cancer Chemotherapy and Pharmacology · 28
Works count: 48
Citation count: 6,866
H-index: 26
I10-index: 28
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