Author

Raymond A. Firestone

Observed names: R A Firestone, R Firestone, R. A. FIRESTONE, R. A. Firestone, R. Firestone, R.A. Firestone, RAYMOND A. FIRESTONE, Raymond A Firestone, Raymond Firestone

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), Princeton University, University of Belgrade, Bristol-Myers Squibb (United States), Zhongnan Hospital of Wuhan University, Boehringer Ingelheim (United States)

OpenAlex ID: A5111696522

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

2002 · Gene M. Dubowchik, Raymond A. Firestone, et al. · Bioconjugate Chemistry · 566

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates

1993 · P. A. Trail, D. Willner, et al. · Science · 557

Mechanism of 1,3-dipolar cycloadditions

1968 · Raymond A. Firestone · The Journal of Organic Chemistry · 297

Induction of cell death by the lysosomotropic detergent MSDH

2000 · Wei Li, XiMing Yuan, et al. · FEBS Letters · 248

(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin

1993 · David Willner, Pamela A. Trail, et al. · Bioconjugate Chemistry · 228

Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells

1994 · Raymond A. Firestone · Bioconjugate Chemistry · 226

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

1998 · Gene M. Dubowchik, Raymond A. Firestone · Bioorganic & Medicinal Chemistry Letters · 194

The diradical mechanism for 1,3-dipolar cycloadditions and related thermal pericyclic reactions

1977 · Raymond A. Firestone · Tetrahedron · 192

Cell killing by lysosomotropic detergents.

1983 · D K Miller, E Griffiths, et al. · The Journal of Cell Biology · 176

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

1986 · James B. Doherty, Bonnie M. Ashe, et al. · Nature · 169

Application of the Linnett electronic theory to organic chemistry. V. Orientation in 1,3-dipolar cycloadditions according to the diradical mechanism. Partial formal charges in the Linnett structures of the diradical intermediate

1972 · Raymond A. Firestone · The Journal of Organic Chemistry · 143

Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers: Inhibition of Aggregation by Methoxytriethyleneglycol Chains

2002 · H. Dalton King, Gene M. Dubowchik, et al. · Journal of Medicinal Chemistry · 137

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents

1979 · Raymond A. Firestone, Judith M. Pisano, et al. · Journal of Medicinal Chemistry · 134

Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin

1998 · Gene M. Dubowchik, Kathleen Mosure, et al. · Bioorganic & Medicinal Chemistry Letters · 118

Monocyclic β-lactam inhibitors of human leukocyte elastase

1990 · Raymond A Firestone, Peter L. arker, et al. · Tetrahedron · 105

Crystallographie study of a β-lactam inhibitor complex with elastase at 1.84 Å resolution

1987 · Manuel A. Navia, James P. Springer, et al. · Nature · 102

Selective delivery of cytotoxic compounds to cells by the LDL pathway

1984 · Raymond A. Firestone, Judith M. Pisano, et al. · Journal of Medicinal Chemistry · 94

Synthesis of pyridozine by diels-alder reactions with 4-methyl-5-alkoxy oxazoles

1967 · R.A. Firestone, E.E. Harris, et al. · Tetrahedron · 80

Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Linkers: A Novel Method for Increasing the Potency of Doxorubicin Immunoconjugates

1999 · H. Dalton King, Derek Yurgaitis, et al. · Bioconjugate Chemistry · 75

The role of lysosomal enzymes in killing of mammalian cells by the lysosomotropic detergent N-dodecylimidazole.

1987 · P D Wilson, R A Firestone, et al. · The Journal of Cell Biology · 75

Stereospecificity of 1,3-dipolar cycloadditions of p-nitrobenzonitrile oxide to cis- and trans-dideuterioethylene

1985 · K. N. Houk, Raymond A. Firestone, et al. · Journal of the American Chemical Society · 75

Total synthesis of (.+-.)-1-carbacefoxitin and -cefamandole and (.+-.)-1-oxacefamandole

1977 · Raymond A. Firestone, John L. Fahey, et al. · Journal of Medicinal Chemistry · 67

Total synthesis of .beta.-lactam antibiotics. Epimerization of 6(7)-aminopenicillins and cephalosporins from .alpha. to .beta.

1974 · Raymond A. Firestone, Natalie S. Maciejewicz, et al. · The Journal of Organic Chemistry · 62

Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates.

1997 · P A Trail, D Willner, et al. · PubMed · 56

Cathepsin B cleavable novel prodrug Ac‐Phe‐Lys‐PABC‐ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis

2011 · Li‐Hua Shao, Shao‐Ping Liu, et al. · Cancer · 54

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Works count: 138

Citation count: 5,592

H-index: 34

I10-index: 79