Author

Iain M. McLay

Observed names: I. M. MCLAY, I. McLay, I. Mclay, I.M. McLay, Iain M McLay, Iain M. Mclay, Iain McLay, Iain Mclay

Observed institutions: GlaxoSmithKline (United Kingdom), University of Perugia, University of Manchester, Sanofi (France), GlaxoSmithKline (United States), GlaxoSmithKline Research & Development Limited (United Kingdom), University of Sheffield

OpenAlex ID: A5111719625

GRid-INdependent Descriptors (GRIND): A Novel Class of Alignment-Independent Three-Dimensional Molecular Descriptors

2000 · Manuel Pastor, Gabriele Cruciani, et al. · Journal of Medicinal Chemistry · 468

Diversity Profiling and Design Using 3D Pharmacophores: Pharmacophore-Derived Queries (PDQ)

1996 · Stephen D. Pickett, Jonathan S. Mason, et al. · Journal of Chemical Information and Computer Sciences · 156

X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain

2008 · Keith Biggadike, Randy K. Bledsoe, et al. · Journal of Medicinal Chemistry · 111

Synthesis and Structure−Activity Relationships of Long-acting β2Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

2010 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Journal of Medicinal Chemistry · 101

Enhancing the Hit-to-Lead Properties of Lead Optimization Libraries

1999 · Stephen D. Pickett, Iain M. McLay, et al. · Journal of Chemical Information and Computer Sciences · 98

Progesterone Receptor Ligand Binding Pocket Flexibility: Crystal Structures of the Norethindrone and Mometasone Furoate Complexes

2004 · Kevin P. Madauss, Su-Jun Deng, et al. · Journal of Medicinal Chemistry · 91

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

2001 · Iain M. McLay, Frank Halley, et al. · Bioorganic & Medicinal Chemistry · 86

Knowledge-Based Interaction Fingerprint Scoring: A Simple Method for Improving the Effectiveness of Fast Scoring Functions

2006 · Chidochangu P. Mpamhanga, Beining Chen, et al. · Journal of Chemical Information and Modeling · 83

1997 · Richard A. Lewis, Jonathan S. Mason, et al. · Journal of Chemical Information and Computer Sciences · 83

Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series

2006 · Mike Barker, Margaret Clackers, et al. · Journal of Medicinal Chemistry · 79

An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors

2002 · Jeffrey M. McKenna, Frank Halley, et al. · Journal of Medicinal Chemistry · 75

Drug Rings Database with Web Interface. A Tool for Identifying Alternative Chemical Rings in Lead Discovery Programs

2003 · Xiao Qing Lewell, Andrew C. Jones, et al. · Journal of Medicinal Chemistry · 74

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

2009 · Keith Biggadike, Randy K. Bledsoe, et al. · Proceedings of the National Academy of Sciences · 73

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist

2008 · Kevin P. Madauss, Randy K. Bledsoe, et al. · Bioorganic & Medicinal Chemistry Letters · 57

Synthesis and Structure−Activity Relationships of Long-acting β2Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

2009 · Panayiotis A. Procopiou, Victoria J. Barrett, et al. · Journal of Medicinal Chemistry · 45

Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method

2005 · Mike Barker, Margaret Clackers, et al. · Journal of Medicinal Chemistry · 45

Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding

2006 · Holger Scheib, Iain McLay, et al. · Journal of Molecular Modeling · 44

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

2007 · Keith Biggadike, Mohamed Boudjelal, et al. · Journal of Medicinal Chemistry · 41

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

2001 · Alan J Collis, Martyn L Foster, et al. · Bioorganic & Medicinal Chemistry Letters · 40

Selective ETAAntagonists. 5. Discovery and Structure−Activity Relationships of Phenoxyphenylacetic Acid Derivatives

2000 · Peter C. Astles, Thomas J. Brown, et al. · Journal of Medicinal Chemistry · 40

Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener

1992 · Thomas J. Brown, Robert F. Chapman, et al. · Journal of Medicinal Chemistry · 39

A refined model for prediction of hydrogen bond acidity and basicity parameters from quantum chemical molecular descriptors

2009 · Mike Devereux, Paul L. A. Popelier, et al. · Physical Chemistry Chemical Physics · 36

Quantum Isostere Database: A Web-Based Tool Using Quantum Chemical Topology To Predict Bioisosteric Replacements for Drug Design

2009 · Mike Devereux, Paul L. A. Popelier, et al. · Journal of Chemical Information and Modeling · 33

Analysis of Neighborhood Behavior in Lead Optimization and Array Design

2008 · George Papadatos, Anthony W. J. Cooper, et al. · Journal of Chemical Information and Modeling · 32

Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics

2007 · Margaret Clackers, Diane M. Coe, et al. · Bioorganic & Medicinal Chemistry Letters · 30

Works count: 50

Citation count: 2,246

H-index: 25

I10-index: 35