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Mika Yokoyama

Involvement of Tyrosine Kinase-2 in Both the IL-12/Th1 and IL-23/Th17 Axes In Vivo
2011 · Masayuki Ishizaki, Toshihiko Akimoto, et al. · The Journal of Immunology · 108
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Intercalator-linked cisplatin: synthesis and antitumor activity of cis-dichloroplatinum(II) complexes connected to acridine and phenylquinolines by one methylene chain
1998 · Yuji Mikata, Mika Yokoyama, et al. · Inorganica Chimica Acta · 63
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists
2005 · Jun Chiba, Gensuke Takayama, et al. · Bioorganic & Medicinal Chemistry · 35
Sugar-Pendant Diamines
2001 · Yuji Mikata, Yoshie Shinohara, et al. · The Journal of Organic Chemistry · 35
Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models
2011 · Hiroki Shimizu, Tomonori Yamasaki, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist
2009 · Fumihito Muro, Shin Iimura, et al. · Journal of Medicinal Chemistry · 26
A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid
2012 · Masaki Setoguchi, Shin Iimura, et al. · Bioorganic & Medicinal Chemistry · 23
Effect of side chain location in (2-aminoethyl)aminomethyl-2-phenylquinolines as antitumor agents
1998 · Yuji Mikata, Mika Yokoyama, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
2018 · Hideki Terashima, Misato Aonuma, et al. · Pulmonary Pharmacology & Therapeutics · 22
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Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo
2010 · Hiroki Shimizu, Isao Yasumatsu, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist
2004 · Jun Chiba, Nobuo Machinaga, et al. · Bioorganic & Medicinal Chemistry Letters · 20
A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid
2008 · Fumihito Muro, Shin Iimura, et al. · Bioorganic & Medicinal Chemistry · 18
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator
2021 · Mayuko Akiu, Takashi Tsuji, et al. · Chemical and Pharmaceutical Bulletin · 16
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4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist
2006 · Jun Chiba, Shin Iimura, et al. · Chemical and Pharmaceutical Bulletin · 16
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Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists
2006 · Jun Chiba, Shin Iimura, et al. · Bioorganic & Medicinal Chemistry · 15
Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist
2011 · Masaki Setoguchi, Shin Iimura, et al. · Bioorganic & Medicinal Chemistry · 13
Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition
2021 · Mayuko Akiu, Takashi Tsuji, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Identification of 4-[1-[3-chloro-4-[N’-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist
2008 · Fumihito Muro, Shin Iimura, et al. · Bioorganic & Medicinal Chemistry · 10
General Synthesis of Useful Chelating Reagents Having a Sugar Unit, 1,3-Diamino-2-propyl β- d -Glucopyranoside and 1,3-Diamino-2-propyl α- d -Mannopyranoside
1999 · Shigenobu Yano, Yoshie Shinohara, et al. · Chemistry Letters · 7
A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints
2013 · Shinji Tanaka, Tadashi Toki, et al. · Biological and Pharmaceutical Bulletin · 5
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Optimization of NAMPT (Nicotinamide Phosphoribosyltransferase) Activators: Discovery of N,N-Diethyl-1,2-benzoxazole-3-carboxamide Derivatives as Potent NAMPT Activators with Mitigated Mutagenic Risks
2021 · Mayuko Akiu, Takashi Tsuji, et al. · Heterocycles · 4
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Improvement of Pulmonary Function by Oral Treatment with a VLA-4 Antagonist in a Mouse Asthmatic Model
2013 · Gensuke Takayama, Keiko Matsumoto, et al. · Journal of Pharmacological Sciences · 3
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Corrigendum to “Identified a morpholinyl-4-piperidinylacetic acid derivatives as a potent oral active VLA-4 antagonist”
2005 · Jun Chiba, Nobuo Machinaga, et al. · Bioorganic & Medicinal Chemistry Letters
Works count: 23
Citation count: 524
H-index: 15
I10-index: 18
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