Author

Dean Hickman

Observed names: D Hickman, D. Hickman, Hickman, D., Hickman, Dean

Observed institutions: Amgen (United States), University of Washington, TB Alliance, University of Oxford, Abbott (United States), Eikonizo Therapeutics (United States), De Montfort University

ORCID: 0009-0003-6761-9764

Observed ORCID: 0009-0003-6761-9764

OpenAlex ID: A5111761598

Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

2022 · Cynthia Hajal, Giovanni S. Offeddu, et al. · Nature Protocols · 258

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Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

1998 · D Hickman, J P Wang, et al. · PubMed · 222

Discovery ofN-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

2007 · Yujia Dai, Kresna Hartandi, et al. · Journal of Medicinal Chemistry · 187

N-acetyltransferase polymorphism

1991 · Dean Hickman, Edith Sim · Biochemical Pharmacology · 170

Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction

1999 · Gondi N. Kumar, Jennifer Dykstra, et al. · Drug Metabolism and Disposition · 161

Expression of arylamine N -acetyltransferase in human intestine

1998 · D Hickman, J Pope, et al. · Gut · 145

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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

2011 · Yuan Cheng, Ted C. Judd, et al. · Journal of Medicinal Chemistry · 140

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

2019 · Giovanni S. Offeddu, Kristina Haase, et al. · Biomaterials · 110

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Chromosomal localization of human genes for arylamine N-acetyltransferase

1994 · D Hickman, A Risch, et al. · Biochemical Journal · 109

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Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants

1992 · Dean Hickman, Angela Risch, et al. · Pharmacogenetics · 83

Arylamine N-acetyltransferase in human red blood cells

1992 · Alison Ward, Dean Hickman, et al. · Biochemical Pharmacology · 82

Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.

1996 · L A Stanley, E Coroneos, et al. · Journal of Histochemistry & Cytochemistry · 79

Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

2012 · Hongbing Huang, Daniel S. La, et al. · Journal of Medicinal Chemistry · 69

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

2012 · Matthew M. Weiss, Toni Williamson, et al. · Journal of Medicinal Chemistry · 64

Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

2014 · Thomas A. Dineen, Kui Chen, et al. · Journal of Medicinal Chemistry · 62

Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution

2019 · Giovanni S. Offeddu, Luca Possenti, et al. · Small · 57

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Enzyme kinetic properties of human recombinant arylamine n-acetyltransferase 2 allotypic variants expressed in Escherichia coli

1995 · Dean Hickman, Jairam R. Palamanda, et al. · Biochemical Pharmacology · 56

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes11Abbreviations: MMP, matrix metalloproteinase; MMPI, matrix metalloproteinase inhibitor; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; NBD-PE, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; and MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; DMSO, dimethylsulfoxide; HPLC, high performance liquid chromatography.

2001 · Rebecca J. Gum, Dean Hickman, et al. · Biochemical Pharmacology · 55

2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice

2008 · Lars Johansson, Christopher Fotsch, et al. · Journal of Medicinal Chemistry · 49

Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

2014 · Oleg Epstein, Marian C. Bryan, et al. · Journal of Medicinal Chemistry · 44

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

2016 · Liping H. Pettus, Kristin L. Andrews, et al. · Journal of Medicinal Chemistry · 42

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

2014 · Mark R. Fielden, Jonathan Werner, et al. · Toxicologic Pathology · 42

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

2012 · Thomas A. Dineen, Matthew M. Weiss, et al. · Journal of Medicinal Chemistry · 41

Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor

2024 · Giovanni S. Offeddu, Elena Cambria, et al. · Advanced Science · 36

Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

2019 · Liping H. Pettus, Matthew P. Bourbeau, et al. · Journal of Medicinal Chemistry · 36

Works count: 72

Citation count: 2,882

H-index: 29

I10-index: 44