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Hua Zou

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 · Xu Luo, Imawati Budihardjo, et al. · Cell · 3,625
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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 · Hua Zou, William J Henzel, et al. · Cell · 3,145
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An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
1999 · Hua Zou, Yuchen Li, et al. · Journal of Biological Chemistry · 2,090
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DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 · Xuesong Liu, Hua Zou, et al. · Cell · 1,835
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Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase
2004 · Clifford D. Mol, Douglas R. Dougan, et al. · Journal of Biological Chemistry · 636
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The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
1998 · Xuesong Liu, Peng Li, et al. · Proceedings of the National Academy of Sciences · 529
Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein
2011 · Kathleen Aertgeerts, Robert Skene, et al. · Journal of Biological Chemistry · 449
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HBXIP functions as a cofactor of survivin in apoptosis suppression
2003 · Hiroyuki Marusawa, Shu‐ichi Matsuzawa, et al. · The EMBO Journal · 432
An IAP-IAP Complex Inhibits Apoptosis
2004 · Takehiko Dohi, Kazuya Okada, et al. · Journal of Biological Chemistry · 399
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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer
2004 · Thorsten K. Oost, Chaohong Sun, et al. · Journal of Medicinal Chemistry · 366
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
1999 · Antony Rodriguez, Holt Oliver, et al. · Nature Cell Biology · 332
Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation
2003 · Clifford D. Mol, Kheng B. Lim, et al. · Journal of Biological Chemistry · 274
Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP
2003 · Hua Zou, Ruomei Yang, et al. · Journal of Biological Chemistry · 213
Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate
2015 · Hui Wang, Michael G Klein, et al. · Nature Structural & Molecular Biology · 191
Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease)
1999 · Xuesong Liu, Hua Zou, et al. · Journal of Biological Chemistry · 174
Characterization of the two catalytic domains in histone deacetylase 6
2006 · Hua Zou, Yiqin Wu, et al. · Biochemical and Biophysical Research Communications · 141
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H -pyrazolo[3,4- c ]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships
2018 · Masato Yoshikawa, Morihisa Saitoh, et al. · Journal of Medicinal Chemistry · 118
Discovery of 3-Benzyl-1-( trans -4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors
2018 · Masahiro Ito, Toshio Tanaka, et al. · Journal of Medicinal Chemistry · 65
Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
2017 · Tomohiro Okawa, Yoshio Aramaki, et al. · Journal of Medicinal Chemistry · 59
The dynamic conformational landscape of the protein methyltransferase SETD8
2019 · Shi Chen, Rafal P. Wiewiora, et al. · eLife · 58
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1)
2013 · Zhe Nie, Victoria Feher, et al. · Bioorganic & Medicinal Chemistry Letters · 49
Stoichiometry, Free Energy, and Kinetic Aspects of Cytochromec: Apaf-1 Binding in Apoptosis
1999 · Cherie Purring, Hua Zou, et al. · Journal of the American Chemical Society · 46
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
2017 · Satoshi Mikami, Shinji Nakamura, et al. · Journal of Medicinal Chemistry · 37
Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors
2016 · Taisuke Katoh, Takafumi Takai, et al. · Bioorganic & Medicinal Chemistry · 28
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer
2022 · Wei-Sheng Huang, Feng Li, et al. · Bioorganic & Medicinal Chemistry Letters · 24
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Works count: 43
Citation count: 15,500
H-index: 24
I10-index: 35
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