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Pamela J. Cheshire

Observed names: P J Cheshire, P. J. Cheshire, P.J. Cheshire, Pamela Cheshire, Pamela J Cheshire
OpenAlex ID: A5111763983
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
1995 · Peter J. Houghton, Pamela J. Cheshire, et al. · Cancer Chemotherapy and Pharmacology · 401
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.
2001 · L Dudkin, M B Dilling, et al. · PubMed · 232
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors
1992 · Peter J. Houghton, Pamela J. Cheshire, et al. · Cancer Chemotherapy and Pharmacology · 227
Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice
2004 · Clinton F. Stewart, Markos Leggas, et al. · Cancer Research · 203
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin.
1993 · P J Houghton, P J Cheshire, et al. · PubMed · 161
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
2000 · P J Houghton, C F Stewart, et al. · PubMed · 139
Relationship Between Topotecan Systemic Exposure and Tumor Response in Human Neuroblastoma Xenografts
1998 · William C. Zamboni, Clinton F. Stewart, et al. · JNCI Journal of the National Cancer Institute · 136
Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.
1997 · J Thompson, W C Zamboni, et al. · PubMed · 123
Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.
1999 · M K Danks, C L Morton, et al. · PubMed · 96
Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts.
1999 · J Thompson, E O George, et al. · PubMed · 87
In vivo Evaluation of Ixabepilone (BMS247550), A Novel Epothilone B Derivative, against Pediatric Cancer Models
2005 · Jennifer K. Peterson, Chandra Tucker, et al. · Clinical Cancer Research · 86
Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.
1990 · J A Houghton, L G Williams, et al. · PubMed · 67
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice
2005 · Christopher L. Morton, Lisa Iacono, et al. · Cancer Chemotherapy and Pharmacology · 63
Efficacy of oral irinotecan against neuroblastoma xenografts
1997 · Joyce Thompson, William C. Zamboni, et al. · Anti-Cancer Drugs · 53
Altered irinotecan and SN-38 disposition after intravenous and oral administration of irinotecan in mice bearing human neuroblastoma xenografts.
1998 · W C Zamboni, P J Houghton, et al. · PubMed · 47
Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models.
1998 · W C Zamboni, C F Stewart, et al. · PubMed · 46
Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
1990 · J A Houghton, L G Williams, et al. · PubMed · 46
Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma.
1996 · J A Houghton, P J Cheshire, et al. · PubMed · 45
Evaluation of N-(5-indanylsulfonyl)-N?-(4-chlorophenyl)-urea against xenografts of pediatric rhabdomyosarcoma
1989 · Peter J. Houghton, Janet A. Houghton, et al. · Cancer Chemotherapy and Pharmacology · 43
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
2001 · M N Kirstein, P J Houghton, et al. · PubMed · 41
Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays.
1998 · C A Pawlik, P J Houghton, et al. · PubMed · 34
Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.
2002 · Markos Leggas, Clinton F Stewart, et al. · PubMed · 33
Evaluation of a novel bis-naphthalimide anticancer agent, DMP 840, against human xenografts derived from adult, juvenile, and pediatric cancers
1994 · Peter J. Houghton, Pamela J. Cheshire, et al. · Cancer Chemotherapy and Pharmacology · 33
Development, characterization and therapy of a disseminated model of childhood neuroblastoma in SCID mice
2001 · Joyce Thompson, Sylvie M. Guichard, et al. · Cancer Chemotherapy and Pharmacology · 32
Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts
1992 · Janet A. Houghton, Larry G. Williams, et al. · Cancer Chemotherapy and Pharmacology · 28
Works count: 36
Citation count: 2,613
H-index: 25
I10-index: 32
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