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Natesan Murugesan

The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide
1994 · Philip D. Stein, John T. Hunt, et al. · Journal of Medicinal Chemistry · 136
Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2‘-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics
2004 · Natesan Murugesan, Zhengxiang Gu, et al. · Journal of Medicinal Chemistry · 91
Bleomycin as an oxene transferase. Catalytic oxygen transfer to olefins
1985 · Natesan Murugesan, Sidney M. Hecht · Journal of the American Chemical Society · 88
Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG)
1988 · Hiroshi Sugiyama, Cheng Xu, et al. · Biochemistry · 84
Analysis of products formed during bleomycin-mediated DNA degradation
1985 · Natesan Murugesan, Cheng Xu, et al. · Biochemistry · 72
Structure of the alkali-labile product formed during iron(II)-bleomycin-mediated DNA strand scission
1985 · Hiroshi Sugiyama, Cheng Xu, et al. · Journal of the American Chemical Society · 70
Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist
2002 · Natesan Murugesan, Zhengxiang Gu, et al. · Journal of Medicinal Chemistry · 64
The chemistry of vicinal tricarbonyls. A stable vinyl tricarbonyl hydrate as a di- and trielectrophile
1989 · Harry H. Wasserman, James Fukuyama, et al. · Journal of the American Chemical Society · 64
Activation of oxygen and mediation of DNA degradation by manganese-bleomycin
1984 · Guy M. Ehrenfeld, Natesan Murugesan, et al. · Inorganic Chemistry · 61
Discovery of N-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists
2002 · Natesan Murugesan, John E. Tellew, et al. · Journal of Medicinal Chemistry · 55
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase
2005 · David S. Weinstein, Wen Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 54
Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension
2004 · Mark C. Kowala, Natesan Murugesan, et al. · Journal of Pharmacology and Experimental Therapeutics · 52
Oxygen transfer by bleomycin analogs dysfunctional in DNA cleavage
1985 · Robert E. Kilkuskie, Hosbett Suguna, et al. · Journal of the American Chemical Society · 49
Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino- N - (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)
1998 · Natesan Murugesan, Zhengxiang Gu, et al. · Journal of Medicinal Chemistry · 42
Mercaptoacyl dipeptides as dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Preliminary structure-activity studies
1994 · Norma G. Delaney, Joel C. Barrish, et al. · Bioorganic & Medicinal Chemistry Letters · 40
Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists
2000 · Natesan Murugesan, Zhengxiang Gu, et al. · Journal of Medicinal Chemistry · 36
Karachine: an unusual protoberberine alkaloid
1982 · Gabor Blasko, Natesan Murugesan, et al. · Journal of the American Chemical Society · 34
Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides
1994 · Jeffrey A. Robl, Ligaya M. Simpkins, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Deglycobleomycin: total synthesis and oxygen transfer properties of an active bleomycin analog
1982 · Yoshiaki Aoyagi, H. Suguna, et al. · Journal of the American Chemical Society · 33
Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists
2003 · John E Tellew, Rose Ann F Baska, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Revised structure for fumarofine, an indenobenzazepine type alkaloid
1981 · Gábor Blaskó, Natesan Murugesan, et al. · Tetrahedron Letters · 24
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis
2020 · Satheesh Nair, Sreekantha Ratna Kumar, et al. · ACS Medicinal Chemistry Letters · 21
Reduction of Site-Specific CYP3A-Mediated Metabolism for Dual Angiotensin and Endothelin Receptor Antagonists in Various in Vitro Systems and in Cynomolgus Monkeys
2007 · Hongjian Zhang, Donglu Zhang, et al. · Drug Metabolism and Disposition · 18
An efficient conversion of berberine into a rhoeadine via an indenobenzazepine
1981 · Natesan Murugesan, Gábor Blaskó, et al. · Tetrahedron Letters · 16
Revised structures for fumaritridine and fumaritrine: Two indenobenzazepine type alkaloids
1981 · Gábor Blaskó, Natesan Murugesan, et al. · Tetrahedron Letters · 16
Works count: 42
Citation count: 1,377
H-index: 21
I10-index: 29
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