Author

Jean‐Louis Steimer

Observed names: J L Steimer, J. -L. Steimer, J. L. Steimer, J.-L. Steimer, J.L. Steimer, J.‐L. Steimer, Jean -Louis Steimer, Jean-Louis J. Steimer, Jean-Louis Steimer, Steimer, J.L.

Institution: Novartis (Switzerland)

Observed institutions: F. Hoffmann-La Roche AG, Novartis (Switzerland), Inserm, University of California, San Francisco, Georgetown University, Hôpital Saint-Antoine, Pitié-Salpêtrière Hospital, Sandoz Group AG (Switzerland), Université Pierre-et-Marie-Curie, Virginia Commonwealth University Medical Center

OpenAlex ID: A5111832231

Pharmacokinetic/Pharmacodynamic Modeling in Drug Development

2000 · L. B. Sheiner, J.-L. Steimer · The Annual Review of Pharmacology and Toxicology · 351

Alternative Approaches to Estimation of Population Pharmacokinetic Parameters: Comparison with the Nonlinear Mixed-Effect Model

1984 · Jean-Louis Steimer, Alain Mallet, et al. · Drug Metabolism Reviews · 275

Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model

2006 · P. Jacqmin, E. Snoeck, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 165

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

1994 · Ryosei Kawai, Michel Lemaire, et al. · Journal of Pharmacokinetics and Biopharmaceutics · 145

The Use of Population Pharmacokinetics in Drug Development

1996 · Samuel Vozeh, Jean-Louis Steimer, et al. · Clinical Pharmacokinetics · 133

Role of modelling and simulation in Phase I drug development

2001 · Leon Aarons, Mats O. Karlsson, et al. · European Journal of Pharmaceutical Sciences · 130

An Evaluation of the Integration of Pharmacokinetic and Pharmacodynamic Principles in Clinical Drug Development

1997 · Bruno G. Reigner, Peter E.O. Williams, et al. · Clinical Pharmacokinetics · 121

Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients

2003 · Ronald Gieschke, Hans‐Ulrich Burger, et al. · British Journal of Clinical Pharmacology · 112

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Non-Linear Mixed Effects Modeling – From Methodology and Software Development to Driving Implementation in Drug Development Science

2005 · Goonaseelan (Colin) Pillai, France Mentré, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 99

Relationships Between Exposure to Saquinavir Monotherapy and Antiviral Response in HIV-Positive Patients

1999 · Ronald Gieschke, B??rbel Fotteler, et al. · Clinical Pharmacokinetics · 97

Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

1988 · Alain Mallet, France Mentré, et al. · Journal of Pharmacokinetics and Biopharmaceutics · 93

A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

2004 · Goonaseelan Pillai, Ronald Gieschke, et al. · British Journal of Clinical Pharmacology · 87

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Feedback Control Methods for Drug Dosage Optimisation

1985 · Samuel Vožeh, Jean-Louis Steimer · Clinical Pharmacokinetics · 67

New strategies in drug development and clinical evaluation: the population approach

1993 · L. P. Balant, M. Rowland, et al. · European Journal of Clinical Pharmacology · 65

On the dose dependency of Cyclosporin a absorption and disposition in healthy volunteers

1988 · Jean-Philippe Reymond, Jean-Louis Steimer, et al. · Journal of Pharmacokinetics and Biopharmaceutics · 64

Clinical Pharmacokinetic/Pharmacodynamic and Physiologically based Pharmacokinetic Modeling in New Drug Development: The Capecitabine Experience

2003 · Karen S. Blesch, Ronald Gieschke, et al. · Investigational New Drugs · 59

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

1996 · L. Aarons, M. Rowland, et al. · European Journal of Clinical Pharmacology · 59

The Population Approach: Rationale, Methods, and Applications in Clinical Pharmacology and Drug Development

1994 · J.-L. Steimer, S. Vozeh, et al. · Handbook of experimental pharmacology · 55

A Time-Lag Model for Pharmacokinetics of Drugs Subject to Enterohepatic Circulation

1982 · Jean-Louis Steimer, Yves Plusquellec, et al. · Journal of Pharmaceutical Sciences · 53

APriori lithium dosage regimen using population characteristics of pharmacokinetic parameters

1979 · Jean Gaillot, Jean-Louis J. Steimer, et al. · Journal of Pharmacokinetics and Biopharmaceutics · 51

A mathematical model for dynamics of cardiovascular drug action: Application to intravenous dihydropyridines in healthy volunteers

1993 · Patrice Francheteau, Jean -Louis Steimer, et al. · Journal of Pharmacokinetics and Biopharmaceutics · 41

Pharmacokinetic and pharmacodynamic data and models in clinical trials

1993 · J. L. Steimer, M. E. Ebelin, et al. · European Journal of Drug Metabolism and Pharmacokinetics · 41

Population Pharmacokinetic Analysis of the Major Metabolites of Capecitabine

2002 · R. Gieschke, B. Reigner, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 39

Sparse sampling for assessment of drug exposure in toxicological studies

1996 · P. Burtin, F. Mentre, et al. · European Journal of Drug Metabolism and Pharmacokinetics · 39

Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

1989 · G. Thomas, C. Girre, et al. · European Journal of Clinical Pharmacology · 37

Works count: 69

Citation count: 2,937

H-index: 30

I10-index: 44