Author

Jacquelynn J. Cook

Observed names: J J Cook, J. Cook, J. J. COOK, J. J. Cook, J.J. Cook, Jacquelyn Cook, Jacquelyn J. Cook, Jacquelynn Cook, Jacquelynn J Cook, Jacquelynn J. Cook

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), Maryville College, Hospital of the University of Pennsylvania, MSD (Belgium), University of Pennsylvania, Temple University, KU Leuven

OpenAlex ID: A5111869052

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

1990 · R. J. Gould, M. A. Polokoff, et al. · Experimental Biology and Medicine · 492

Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms.

1990 · J Musial, S Niewiarowski, et al. · Circulation · 133

PDF

In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

2013 · Eric D. Hostetler, Aniket D. Joshi, et al. · Journal of Pharmacology and Experimental Therapeutics · 130

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

2003 · Christopher S. Burgey, Kyle A. Robinson, et al. · Journal of Medicinal Chemistry · 119

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

2008 · Sethu Sankaranarayanan, Marie A. Holahan, et al. · Journal of Pharmacology and Experimental Therapeutics · 107

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

1998 · Thomas J. Tucker, Stephen F. Brady, et al. · Journal of Medicinal Chemistry · 106

Species Variability in Platelet and other Cellular Responsiveness to Thrombin Receptor-derived Peptides

1994 · Thomas M Connolly, Cindra Condra, et al. · Thrombosis and Haemostasis · 99

Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

2004 · Mary Beth Young, James C. Barrow, et al. · Journal of Medicinal Chemistry · 97

An Antibody Against the Exosite of the Cloned Thrombin Receptor Inhibits Experimental Arterial Thrombosis in the African Green Monkey

1995 · Jacquelynn J. Cook, Gary R. Sitko, et al. · Circulation · 93

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

2010 · Christopher A. Salvatore, Eric L. Moore, et al. · Journal of Pharmacology and Experimental Therapeutics · 89

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

1998 · Philip E. J. Sanderson, Terry A. Lyle, et al. · Journal of Medicinal Chemistry · 86

A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody

2011 · Helmut Glantschnig, Kevin Scott, et al. · Journal of Pharmacology and Experimental Therapeutics · 84

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

1998 · Stephen F. Brady, Kenneth J. Stauffer, et al. · Journal of Medicinal Chemistry · 78

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venon of trimeresurus albolabris: Significance for the express of platelet aggregation inhibitory activity

1991 · Juan J. Calvete, Wolfram Schaefer, et al. · Biochemistry · 78

Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound

2010 · Jacquelynn J. Cook, Kristin R. Wildsmith, et al. · Journal of Neuroscience · 72

PDF

Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383.

1995 · J J Lynch, J J Cook, et al. · Journal of Pharmacology and Experimental Therapeutics · 69

Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

2012 · Guoxin Wu, Sethu Sankaranarayanan, et al. · Journal of Neuroscience Research · 68

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

1998 · Philip E.J. Sanderson, Kellie J. Cutrona, et al. · Bioorganic & Medicinal Chemistry Letters · 68

Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs

1996 · John H. Hutchinson, Jacquelynn J. Cook, et al. · Journal of Medicinal Chemistry · 63

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist

1995 · Mark E. Duggan, Adel M. Naylor-Olsen, et al. · Journal of Medicinal Chemistry · 63

Fibrinogen Receptor Antagonist-Induced Thrombocytopenia in Chimpanzee and Rhesus Monkey Associated With Preexisting Drug-Dependent Antibodies to Platelet Glycoprotein IIb/IIIa

1999 · Bohumil Bednar, Jacquelynn J. Cook, et al. · Blood · 61

Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B 1 Receptor Antagonists

2006 · Scott D. Kuduk, Christina N. Di Marco, et al. · Journal of Medicinal Chemistry · 58

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

1997 · Benny C. Askew, Rodney A. Bednar, et al. · Journal of Medicinal Chemistry · 55

BOLD and blood volume-weighted fMRI of rat lumbar spinal cord during non-noxious and noxious electrical hindpaw stimulation

2007 · Fuqiang Zhao, Mangay Williams, et al. · NeuroImage · 50

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

1999 · Melissa S. Egbertson, Jacquelynn J. Cook, et al. · Journal of Medicinal Chemistry · 50

Works count: 113

Citation count: 3,929

H-index: 37

I10-index: 73