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Margaret van Heek

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
1997 · M Van Heek, D S Compton, et al. · Journal of Clinical Investigation · 752
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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
2017 · Robert W. Myers, Hong-Ping Guan, et al. · Science · 345
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
2000 · Margaret Van Heek, Constance Farley, et al. · British Journal of Pharmacology · 325
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In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461
1997 · Margaret Van Heek, Constance F. France, et al. · Journal of Pharmacology and Experimental Therapeutics · 306
Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague‐Dawley Rats
2002 · Lorraine Ghibaudi, John Cook, et al. · Obesity Research · 219
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Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
2001 · Margaret Van Heek, Constance Farley, et al. · British Journal of Pharmacology · 218
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Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice
1997 · J. J. Hwa, A. B. Fawzi, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 199
Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
2008 · Shuqin Zheng, Lizbeth Hoos, et al. · European Journal of Pharmacology · 163
The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys
2001 · Margaret van Heek, Douglas S Compton, et al. · European Journal of Pharmacology · 130
Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status
2002 · Eric Parker, Margaret Van Heek, et al. · European Journal of Pharmacology · 97
Engineering Glucose Responsiveness Into Insulin
2017 · Niels C. Kaarsholm, Songnian Lin, et al. · Diabetes · 91
Ezetimibe, a Potent Cholesterol Absorption Inhibitor, Normalizes Combined Dyslipidemia in Obese Hyperinsulinemic Hamsters
2001 · Margaret van Heek, Theodore M. Austin, et al. · Diabetes · 79
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Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity
2005 · Anandan Palani, Sherry Shapiro, et al. · Journal of Medicinal Chemistry · 61
Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats
2003 · Margaret Van Heek, Constance Farley, et al. · British Journal of Pharmacology · 60
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The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans
2012 · Roshni R. Singaraja, Suthesh Sivapalaratnam, et al. · Circulation Cardiovascular Genetics · 59
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Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461
1996 · Syndeep Dugar, Nathan Yumibe, et al. · Bioorganic & Medicinal Chemistry Letters · 58
Effect of Chronic Central Administration of Glucagon‐Like Peptide‐1 (7–36) Amide on Food Consumption and Body Weight in Normal and Obese Rats
1998 · Harry R. Davis, Deborra E. Mullins, et al. · Obesity Research · 55
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The Liptin Haemopoietic Cytokine Fold is Stabilized by an Intrachain Disulfide Bond
1996 · F. Rock, S. Altmann, et al. · Hormone and Metabolic Research · 54
Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet
2002 · Jun Gao, Lorraine Ghibaudi, et al. · Brain Research · 49
The Relationship of Tissue Localization, Distribution and Turnover to Feeding After Intraperitoneal125I-Leptin Administration toob/obanddb/dbMice
1996 · M. Van Heek, D. Mullins, et al. · Hormone and Metabolic Research · 49
Mechanisms of hypertriglyceridemia in the coconut oil/cholesterol-fed rabbit. Increased secretion and decreased catabolism of very low density lipoprotein.
1991 · M Van Heek, D B Zilversmit · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · 47
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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
2019 · Eric S. Muise, Hong-Ping Guan, et al. · PLoS ONE · 42
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Development of Novel Benzomorpholine Class of Diacylglycerol Acyltransferase I Inhibitors
2014 · Gang Zhou, Nicolas Zorn, et al. · ACS Medicinal Chemistry Letters · 36
Postprandial lipemia and lipoprotein lipase in the rabbit are modified by olive and coconut oil.
1990 · M Van Heek, D B Zilversmit · Arteriosclerosis An Official Journal of the American Heart Association Inc · 32
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Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
2011 · Anandan Palani, Ashwin U. Rao, et al. · ACS Medicinal Chemistry Letters · 27
Works count: 58
Citation count: 3,922
H-index: 26
I10-index: 43
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