Author

Yusheng Xiong

Observed name: Xiong, Yusheng

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), Duke University, Wayne State University, University of Chicago, Duke Medical Center, Massachusetts Institute of Technology, University of Glasgow

ORCID: 0000-0001-7407-4596

Observed ORCID: 0000-0001-7407-4596

OpenAlex ID: A5111895310

Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry

1998 · Susan P. Rohrer, Elizabeth T. Birzin, et al. · Science · 452

Magnesium amide bases and amido-Grignards. 1. Ortho magnesiation

1989 · Philip E. Eaton, Chih Hung Lee, et al. · Journal of the American Chemical Society · 229

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors

2021 · Thomas J. Tucker, Mark W. Embrey, et al. · Journal of Medicinal Chemistry · 159

Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design

2020 · Candice Alleyne, Rupesh P. Amin, et al. · Journal of Medicinal Chemistry · 135

Systematic substitution on the cubane nucleus. Synthesis and properties of 1,3,5-trinitrocubane and 1,3,5,7-tetranitrocubane

1993 · Philip E. Eaton, Yusheng Xiong, et al. · Journal of the American Chemical Society · 91

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

2019 · Whitney L. Petrilli, Gregory C. Adam, et al. · Cell chemical biology · 88

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Regiochemical Variations in Reactions of Methylcubane with tert-Butoxyl Radical, Cytochrome P-450 Enzymes, and a Methane Monooxygenase System

1996 · Seung-Yong Choi, Philip E. Eaton, et al. · Journal of the American Chemical Society · 88

Discovery of a Novel Glucagon Receptor AntagonistN-[(4-{(1S)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes

2012 · Yusheng Xiong, Jian Guo, et al. · Journal of Medicinal Chemistry · 87

The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets

2012 · Xiaoyan (Nina) Li, James Herrington, et al. · Journal of Pharmacology and Experimental Therapeutics · 78

Glucagon receptor antagonism induces increased cholesterol absorption

2015 · Hong-Ping Guan, Xiaodong Yang, et al. · Journal of Lipid Research · 76

On the Mechanism of Toluene Disproportionation in a Zeolite Environment

1995 · Yusheng Xiong, Paul G. Rodewald, et al. · Journal of the American Chemical Society · 73

Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity

2010 · Changyou Zhou, Margareta Garcia-Calvo, et al. · Journal of Medicinal Chemistry · 51

Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

2012 · James Mu, Sajjad A. Qureshi, et al. · PLoS ONE · 49

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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection

2005 · Yusheng Xiong, Judyann Wiltsie, et al. · Bioorganic & Medicinal Chemistry Letters · 48

Orientational disorder in solid cubane: a thermodynamic and carbon-13 NMR study

1992 · Mary Anne White, Roderick E. Wasylishen, et al. · The Journal of Physical Chemistry · 46

Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

2001 · Ranabir Sinha Roy, Ping Yang, et al. · Chemistry & Biology · 42

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Cubyl cation

1990 · Philip E. Eaton, Cheng Xi Yang, et al. · Journal of the American Chemical Society · 41

Label-Free High-Throughput Screening via Mass Spectrometry: A Single Cystathionine Quantitative Method for Multiple Applications

2009 · Tom G. Holt, Bernard K. Choi, et al. · Assay and Drug Development Technologies · 37

Identification of Novel and Selective KV2 Channel Inhibitors

2011 · James Herrington, Kelli Solly, et al. · Molecular Pharmacology · 33

Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders

2022 · Hong-Ping Guan, Yusheng Xiong · Frontiers in Pharmacology · 26

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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

2015 · Scott B. Hoyt, Min K. Park, et al. · ACS Medicinal Chemistry Letters · 26

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

2015 · Jason E. Imbriglio, Dong-Ming Shen, et al. · Journal of Medicinal Chemistry · 25

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension

2017 · Scott B. Hoyt, Jerry Taylor, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Systematic substitution on the cubane nucleus: steric and electronic effects

1992 · Philip E. Eaton, Yusheng Xiong, et al. · The Journal of Organic Chemistry · 21

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

2015 · Scott B. Hoyt, Whitney Petrilli, et al. · ACS Medicinal Chemistry Letters · 20

Works count: 47

Citation count: 2,190

H-index: 23

I10-index: 34