Get started
Author

Thomas S. McIntosh

Development of Different Analysis Platforms with LC−MS for Pharmacokinetic Studies of Protein Drugs
2009 · Qiaozhen Lu, Xiaoyang Zheng, et al. · Analytical Chemistry · 83
A Liquid Chromatography–Mass Spectrometry Method to Measure Stable Isotopic Tracer Enrichments of Glycerol and Glucose in Human Serum
2002 · T.S. McIntosh, H.M. Davis, et al. · Analytical Biochemistry · 78
Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction.
1999 · J Q Tran, S J Kovacs, et al. · PubMed · 78
Theoretical Considerations and Practical Approaches to Address the Effect of Anti-drug Antibody (ADA) on Quantification of Biotherapeutics in Circulation
2013 · Marian Kelley, Ago B. Ahene, et al. · The AAPS Journal · 71
PDF
Morning Spot and 24‐Hour Urinary 6β‐Hydroxycortisol to Cortisol Ratios: Intraindividual Variability and Correlation under Basal Conditions and Conditions of CYP 3A4 Induction
1999 · Jonathan Q. Tran, Steven J. Kovacs, et al. · The Journal of Clinical Pharmacology · 69
Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys
2013 · Weirong Wang, Xiaofeng Wang, et al. · The AAPS Journal · 46
PDF
Utility of free and total target measurements as target engagement and efficacy biomarkers in biotherapeutic development—Opportunities and challenges
2015 · Songmao Zheng, Thomas McIntosh, et al. · The Journal of Clinical Pharmacology · 38
Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data
2013 · Gerald J. Fetterly, Urvi Aras, et al. · The Journal of Clinical Pharmacology · 37
Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty Rats
2002 · Beat M. Jucker, Thomas R. Schaeffer, et al. · Diabetes · 28
PDF
Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice
2018 · Xi Chen, Xiling Jiang, et al. · Journal of Pharmacology and Experimental Therapeutics · 26
PDF
Type-specific protection of neonatal rats from lethal group B streptococcal infection by immune sera obtained from human volunteers vaccinated with type III-specific polysaccharide
1982 · B J De Cueninck, T K Eisenstein, et al. · Infection and Immunity · 21
PDF
Quantitation of in vitro opsonic activity of human antibody induced by a vaccine consisting of the type III-specific polysaccharide of group B streptococcus
1983 · B J De Cueninck, T K Eisenstein, et al. · Infection and Immunity · 17
PDF
Best practices for optimization and validation of flow cytometry‐based receptor occupancy assays
2020 · Ed Hilt, Yongliang S. Sun, et al. · Cytometry Part B Clinical Cytometry · 13
PDF
A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines
2013 · Brian J. Geist, Darryl Davis, et al. · mAbs · 6
PDF
Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model
2015 · Weirong Wang, Thomas S. McIntosh, et al. · Pharmaceutical Research · 5
A Novel Approach to Evaluate the Pharmacokinetic Biocomparability of a Monoclonal Antibody Derived from Two Different Cell Lines Using Simultaneous Crossover Design
2013 · Chao Han, Thomas S. McIntosh, et al. · The AAPS Journal · 3
PDF
Abstract 2518: A novel preclinical study in cynomolgus monkeys examining CCL2 production rate and kinetic profile after escalating dose administration of anti-CCL2 human monoclonal antibody carlumab (CNTO 888)
2012 · Thomas Puchalski, Chao Han, et al. · Cancer Research · 3
Abstract A37: Development of biologics targeting soluble ligands: Novel biomarker and PK-PD analyzes examining free and total ligand profile following treatment with carlumab (anti-CCL2 mAb).
2011 · Shobha Seetharam, Thomas A. Puchalski, et al. · Molecular Cancer Therapeutics · 1
Works count: 18
Citation count: 623
H-index: 13
I10-index: 13
Year
Topic
Type