Author

Jeffrey R. Spencer

Observed names: JEFFREY R. SPENCER, Jeffrey R Spencer, Jeffrey Spencer

Observed institutions: California Institute of Technology, University of California San Diego, STATegics (United States)

OpenAlex ID: A5111948751

Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

2001 · Erik Verner, Bradley A. Katz, et al. · Journal of Medicinal Chemistry · 124

Comparative study of methods to couple hindered peptides

1992 · JEFFREY R. SPENCER, VALERY V. ANTONENKO, et al. · International journal of peptide & protein research · 75

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site11Edited by D. Rees

2001 · Bradley A Katz, Kyle Elrod, et al. · Journal of Molecular Biology · 72

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

2001 · Bradley A Katz, Paul A Sprengeler, et al. · Chemistry & Biology · 64

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Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G

2006 · Jonathan W. Lane, Alberto Estevez, et al. · Bioorganic & Medicinal Chemistry Letters · 59

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

2003 · Bradley A. Katz, Kyle Elrod, et al. · Journal of Molecular Biology · 40

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease

2002 · David Sperandio, Anthony R. Gangloff, et al. · Bioorganic & Medicinal Chemistry Letters · 40

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

2002 · Richard L. Mackman, Hon C. Hui, et al. · Bioorganic & Medicinal Chemistry Letters · 33

Cyclic hexapeptide analogs of somatostatin containing bridge modifications

1993 · ZIWEI HUANG, ALBERT PRÖBSTL, et al. · International journal of peptide & protein research · 30

Structure-Guided Design of Peptide-Based Tryptase Inhibitors

2006 · Mary E. McGrath, Paul A. Sprengeler, et al. · Biochemistry · 27

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

2002 · Jeffrey R Spencer, Danny McGee, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Design and Evaluation of Potent Inhibitors of Asparagine-Linked Protein Glycosylation

1996 · Tamara L. Hendrickson, Jeffrey R. Spencer, et al. · Journal of the American Chemical Society · 24

Structural and Functional Characterization of a Constrained Asx-Turn Motif

1994 · Barbara Imperiali, Jeffrey R. Spencer, et al. · Journal of the American Chemical Society · 23

Agonists of the Tissue-Protective Erythropoietin Receptor in the Treatment of Parkinson’s Disease

2015 · Juha Punnonen, James Miller, et al. · Current Topics in Medicinal Chemistry · 22

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors

2006 · James T. Palmer, Robert M. Rydzewski, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors

2002 · Bradley A. Katz, Jeffrey R. Spencer, et al. · Journal of the American Chemical Society · 22

Discovery of novel hydroxy pyrazole based factor IXa inhibitor

2006 · Dange Vijaykumar, Paul A. Sprengeler, et al. · Bioorganic & Medicinal Chemistry Letters · 21

Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor

2015 · James L. Miller, Timothy J. Church, et al. · Molecular Pharmacology · 18

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Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay

2007 · John Drewe, Shailaja Kasibhatla, et al. · Bioorganic & Medicinal Chemistry Letters · 18

Unusual peptide bond cleavage reactions during acidolytic deprotection reactions

1993 · Jeffrey R. Spencer, Nancy G. J. Delaet, et al. · The Journal of Organic Chemistry · 18

Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo

2006 · Jeffrey R. Spencer, Martin Sendzik, et al. · Bioorganic & Medicinal Chemistry Letters · 16

Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles

2006 · Chang-Sun Lee, Weili Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 16

Discovery and structure–activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers

2006 · Vincent W.-F. Tai, David Sperandio, et al. · Bioorganic & Medicinal Chemistry Letters · 14

Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in vivo

2017 · James L. Miller, Myriam Rai, et al. · Neuropharmacology · 13

Novel, potent, selective, and orally bioavailable human βII-tryptase inhibitors

2006 · David Sperandio, Vincent W.-F. Tai, et al. · Bioorganic & Medicinal Chemistry Letters · 11

Works count: 34

Citation count: 867

H-index: 18

I10-index: 26